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08 November 2022: Articles

Apixaban-Associated Diffuse Alveolar Hemorrhage in an Elderly Man with Multiple Complications

Unusual clinical course, Adverse events of drug therapy

Takuya Ozawa A , Hideki Terai A* , Akiyoshi Kajino A , Shiro Otake A , Ayaka Saito A , Miyuki Nishie A , Yoshikazu Kishino A , Hirofumi Kamata A , Kentaro Hayashida A , Makoto Ishii A , Koichi Fukunaga A

DOI: 10.12659/AJCR.937809

Am J Case Rep 2022; 23:e937809

Table 1. Cases of direct oral anticoagulant-induced alveolar hemorrhage.

AuthorDrugAge (y)SexDosing periodPreceding eventsDrug discontinuationSupportive care
This caseApixaban80M1 ySurgery+Intubated
Gabrilovich et al []9 79F2 wCPAP
Ito et al []10 Rivaroxaban80F2 yRenal dysfunction+
Kilic et al []11 89F6 mRenal dysfunction+NIMV
Nitta et al []12 Edoxaban51F35 dFungus infection+Intubated
Shankar et al []13 Dabigatran86MRenal dysfunctionIntubated
Yokoi et al []14 78M2 mIntubated
Shiroshita et al []15 81M5 yFever/sore throat/ nasal congestion+Oxygen via cannula
Husari et al []16 85M4 m+NIMV
Kudo et al []17 74F3 mOverdose+
y – year; m – month; w – week; d – day.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923