Apixaban-Associated Diffuse Alveolar Hemorrhage in an Elderly Man with Multiple Complications

Takuya Ozawa; Hideki Terai; Akiyoshi Kajino; Shiro Otake; Ayaka Saito; Miyuki Nishie; Yoshikazu Kishino; Hirofumi Kamata; Kentaro Hayashida; Makoto Ishii; Koichi Fukunaga

doi:10.12659/AJCR.937809

08 November 2022 : Case report Japan

Apixaban-Associated Diffuse Alveolar Hemorrhage in an Elderly Man with Multiple Complications

Unusual clinical course, Adverse events of drug therapy

Takuya Ozawa^1ABCDE, Hideki Terai^1ACDE*, Akiyoshi Kajino^2ABC, Shiro Otake^1ABCDE, Ayaka Saito^1ABC, Miyuki Nishie^1ABCD, Yoshikazu Kishino^2ABC, Hirofumi Kamata^1ABCD, Kentaro Hayashida

^2ABCD, Makoto Ishii

^1ABC, Koichi Fukunaga^1ABCD

DOI: 10.12659/AJCR.937809

Am J Case Rep 2022; 23:e937809

Authors information Article notes Copyright and License information

Background Case Report Discussion Conclusions References:

Related articles Order reprints Share article Share by email

View HTML version

Table 1. Cases of direct oral anticoagulant-induced alveolar hemorrhage.

Author	Drug	Age (y)	Sex	Dosing period	Preceding events	Drug discontinuation	Supportive care
This case	Apixaban	80	M	1 y	Surgery	+	Intubated
Gabrilovich et al []⁹		79	F	2 w			CPAP
Ito et al []¹⁰	Rivaroxaban	80	F	2 y	Renal dysfunction	+
Kilic et al []¹¹		89	F	6 m	Renal dysfunction	+	NIMV
Nitta et al []¹²	Edoxaban	51	F	35 d	Fungus infection	+	Intubated
Shankar et al []¹³	Dabigatran	86	M		Renal dysfunction		Intubated
Yokoi et al []¹⁴		78	M	2 m			Intubated
Shiroshita et al []¹⁵		81	M	5 y	Fever/sore throat/ nasal congestion	+	Oxygen via cannula
Husari et al []¹⁶		85	M	4 m		+	NIMV
Kudo et al []¹⁷		74	F	3 m	Overdose	+
y – year; m – month; w – week; d – day.

Back to the Article

Apixaban-Associated Diffuse Alveolar Hemorrhage in an Elderly Man with Multiple Complications

Your Privacy