08 October 2022
: Case report 
Lupus Anticoagulant-Hypoprothrombinemia Syndrome and Pseudotumor Cerebri as an Initial Presentation of Systemic Lupus Erythematosus in a 16-Year-Old Male Patient: A Case Report and Literature Review
Challenging differential diagnosis, Unusual or unexpected effect of treatment, Rare disease, Rare coexistence of disease or pathology
Mohamed H. Omer1DEF, Hind Salama
2AB*, Asim M. Alghaythi2B, Abdullah A. Alharbi3BD, Ghassan AlJohani4ABD
DOI: 10.12659/AJCR.938051
Am J Case Rep 2022; 23:e938051
Table 2. 1: 1 Mixing study of PT and PTT along with lupus anticoagulant detection tests.
| Test | Initial presentation | Reference ranges (units) |
|---|---|---|
| Prothrombin time (control) | 51.10 | 9.38–12.34 (seconds) |
| Prothrombin time (mix) | 15.60 | <10.4 (seconds) |
| Partial thromboplastin time (control) | 112.50 | 24.8–32.6 (seconds) |
| Partial thromboplastin time (mix) | 95.30 | <30.5 (seconds) |
| LA1 | 156.80 | 30.00–40.00 (seconds) |
| LA2 | 92.20 | 26.50–32.50 (seconds) |
| LA1/LA2 ratio | 1.70 | ∼<1.2 Normal1.3–1.4 Indeterminate>1.4 Positive |
| Lupus Anticoagulant | Positive | NA |
| LA1 – lupus anticoagulant screen using dilute Russell’s Viper Venom screening; LA2 – lupus anticoagulant screen using confirmatory reagents. | ||