30 April 2023
: Case report 
Atypical Hemolytic Uremic Syndrome in a Pregnant Patient with a Thrombomodulin Gene Variant Treated with Plasma Exchange and Eculizumab
Challenging differential diagnosis, Unusual setting of medical care, Rare disease
Lakshmi Kannan
12ABCDEF*
DOI: 10.12659/AJCR.938896
Am J Case Rep 2023; 24:e938896
Table 2. Secondary work-up for hypertension and TMA.
| SCL70 | Negative |
| PNH w/FLAER | No evidence of PNH |
| ACTH | 17 pg/ml (2.2–13.3 pg/ml) |
| Cortisol | 20.62 mcg/dL (5–25 mcg/dL) |
| C3 | 108.7 mg/dL (80–178 mg/dL) |
| C4 | 29.5 mg/dL (12–42 mg/dL) |
| GBM AB | Negative |
| Rheumatoid factor | Negative |
| Anti-histone antibody | Negative |
| Anti-ds-DNA | Negative |
| C-ANCA | Negative |
| SCL – scleroderma antibody; PNH – paroxysmal nocturnal hemoglobinuria; PNH with FLAER – paroxysmal nocturnal hemoglobinuria with high-sensitivity flow cytometry; ACTH – adrenocorticotropic hormone; GBM AB – glomerular basement membrane antibody; ds-DNA – double- stranded DNA; c-ANCA – antineutrophil cytoplasmic antibodies. | |