17 June 2023>: Articles
A 78-Year-Old Man with Chronic Kidney Disease and Monoclonal Gammopathy Who Developed Post-Transplant C3 Glomerulopathy – Recurrence or De Novo? A Case Report and Literature Review
Challenging differential diagnosis, Rare coexistence of disease or pathology
María Carmen Ruiz-Fuentes A* , Mercedes Caba-Molina D , Aurora Polo-Moyano B , Magdalena Palomares-Bayo B , Pilar Galindo-Sacristán B , Carmen De Gracia-Guindo EDOI: 10.12659/AJCR.939726
Am J Case Rep 2023; 24:e939726
Table 2. Histology.
One epithelial crescent | |
Mild segmentary and focal increase of mesangial cells number | |
Tubules: loss of brush edging, pyknosis and nuclear irregularity, cell release, epithelial flattening, and some signs of mitosis. Some cylinders with a hematic component | |
Glomerulitis | g0 |
Interstitial inflammation | i0-1 |
Tubulitis | t0 |
Mild capillaritis | ptc1 |
Chronic damage of interstitial fibrosis | ci1 |
Mild tubular atrophy (“thyroidization”) | ct1 |
Intimal thickening | cv2 |
C4d | Negative |
SV40 | Negative |
Congo red | Negative |
C3 ++/+++. Global deposit, scarce but very intense deposit in mesangial and paramesangial areas | |
C4d ++ presence in glomerulus, in 2 of the 3, negative in peritubular capillaries | |
IgA and IgG traces, and kappa and lambda chains in the glomerulus | |
Positivity for IgA, kappa and lambda in tubular cylinders |