21 September 2023
: Case report 
Prion Disease After COVID-19: A Case Report
Unknown etiology, Challenging differential diagnosis, Rare disease
Karim Makhoul1ABDEF, Tova Beeber1ABCEF, Ryan Cordero1ABE, Areej Khan1ABDEF, Merjona Saliaj1ABDEF*DOI: 10.12659/AJCR.940564
Am J Case Rep 2023; 24:e940564
Table 1. Presenting symptoms in our patient and progression of the disease.
| Presenting symptoms | 1 month into disease course | 2 months into disease course | 3 months into disease course | 4 months into disease course |
|---|---|---|---|---|
| – Forgetfulness – Confusion – Patient referred for neurological evaluation, did not attend | – Bradykinesia– Frequent drooling– Patient noted manually lifting his legs to walk | – COVID-19 positive– Hallucinations– Dysarthria– Hospitalization | – Diffuse muscle rigidity– Myoclonic jerking– Loss of swallow reflex | – Akinetic mutism– Severe paratonia of all limbs– Reemergence of primitive reflexes– Death |