23 December 2023
: Case report 
Hypopharyngeal Diffuse Large B-Cell Lymphoma in a 74-Year-Old Man Presenting with Dysphagia: A Case Report
Unusual clinical course, Challenging differential diagnosis, Rare disease
Hisataka Ominato
12ABCDEF*, Yuki Komabayashi 1AEF, Shiori Suzuki 1AD, Isamu Kunibe 1AF, Takumi Kumai 2AF, Miki Takahara 2AF
DOI: 10.12659/AJCR.942070
Am J Case Rep 2023; 24:e942070
Table 1. Clinical characteristics of reported cases of hypopharyngeal malignant lymphoma.
| Author | Age | Sex | Symptom | Finding | Subsite | Type | Treatment | Progress |
|---|---|---|---|---|---|---|---|---|
| Pak (1999) []7 | 65 | M | Sore throat | Ulcer | Posterior wall | T-cell non-Hodgkin lymphoma | Chemo and RT | DOD (alive at 1 year) |
| Firat (2007) []11 | 61 | F | Dysphagia, sore throat | Non-ulcer | Piriform sinuses, posterior wall | MALT lymphoma | Chemo and RT | CR (5 years) |
| Cordes (2011) []12 | 63 | M | Dysphagia, sore throat | Ulcer | Piriform sinuses | DLBCL | NA | DOD (alive at 10 weeks) |
| Lo Pinto (2018) []13 | 55 | F | Na (dead) | Papillomatous | NA | DLBCL | NA | DOD |
| Al Burshaid (2019) []14 | 28 | M | Voice change | Smooth | Piriform sinuses | Burkitt lymphoma | Chemo | CR (2 years) |
| Fujimoto (2022) []15 | 49 | F | Dysphagia, pharyngeal discomfort | Smooth | Piriform sinuses | Adult T-cell leukemia/lymphoma | Chemo | CR (1 year) |
| Present case | 74 | M | Dysphagia | Smooth | Piriform sinuses | DLBCL | Chemo | CR (2 years) |
| DLBCL – diffuse large B-cell lymphoma; MALT – mucosa-associated lymphoid tissue; NA – not applicable; Chemo – chemotherapy; RT – radiotherapy; DOD – died of disease; CR – complete response. | ||||||||