02 August 2024
: Case report 
Voriconazole-Induced Periostitis: A Mimicker of Skeletal Coccidioidomycosis
Challenging differential diagnosis, Unusual or unexpected effect of treatment, Adverse events of drug therapy, Educational Purpose (only if useful for a systematic review or synthesis)
Priyal J. Shah
1BDEF, Janis E. Blair1BDEF*
DOI: 10.12659/AJCR.944102
Am J Case Rep 2024; 25:e944102
Table 1. Changes in clinical and laboratory parameters with changes in voriconazole dose.
| Voriconazole dose | 300 mg i.v. twice daily | 350 mg i.v. twice daily |
|---|---|---|
| Serum level | 2.6 µg/mL | 2.4 µg/mL |
| Duration of treatment at this dose | 4 weeks | 2 weeks |
| Alkaline phosphatase level (range 35–104 units/L) | 78 units/L | 173 units/L |
| ALT (range 7–43 units/L) | 18 units/L | 17 units/L |
| AST (range 8–45 units/L) | 22 units/L | 18 units/L |
| Clinical response to the symptoms of coccidioidomycosis meningitis | Unchanged | Improved |