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03 November 2024 : Case report  China

Finerenone as a Novel Treatment for Gitelman Syndrome: A Case Study of a 35-Year-Old Male with Adrenal Mass and Hypokalemia

Challenging differential diagnosis, Rare disease, Adverse events of drug therapy

Rujie Jiang1ABCDEF, Qiue Liu1B, Yanan Sun1B, Xiaoqing Dai1C, Feng Xu1D*, Fang Wang1ADEF

DOI: 10.12659/AJCR.944492

Am J Case Rep 2024; 25:e944492

Table 1. Important laboratory findings.

IndicatorResultReference
Serum electrolyte analysisSerum potassium (mmol/l)2.73.5~5.5
Serum magnesium (mmol/l)0.580.75~1.02
Serum chloride (mmol/l)9499~110
Ionized calcium (mmol/l)1.071.1~1.29
Blood gas analysisPH7.447.35~7.45
PCO2 (mmHg)41.235~45
Actual base excess (mmol/L)3.5−3~3
Aldosterone (pg/ml)131.430~160
Renin (ng/mL/hr)8.990.15~2.33
24-hour urine electrolyte testingUrine output (ml)2900
Urine potassium (mmol/24 h)32.8425~100
Urine potassium (g/24 h)3.811.0~3.5
Urine calcium (g/24 h)0.0160.1~0.3
Urine creatinine (g/24 h)1.840.7~1.5
Urine phosphorus (g/24 h)0.590.7~1.7
Fractional excretion of potassium (FEK, %)14.794~10
Urinary microalbumin (mg/L)34.60–30
HbA1c (%)6.83.6–6.0
Anti-human insulin antibody (IU/ml)18.06<20
Glutamic acid decarboxylase antibody (IU/ml)1<30
C-peptide (ng/mL)3.681.1~4.4
INS (uIU/mL)16.583.0–17.0
HbA – glycated hemoglobin A1c; INS – insulin; “–” indicates no reference value.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923