25 December 2025
: Case report 
The Silent Surge: A Case of Rhabdomyolysis-Induced Hypercalcemia
Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents
Moath Fateh
ABCDEF 1*, Tariq Albweitel AE 1, Ahmad Odeh AE 1, Sarah Ghaith ABCDEF 2
DOI: 10.12659/AJCR.950626
Am J Case Rep 2025; 26:e950626
Table 3 Reported cases of delayed hypercalcemia after rhabdomyolysis.
| Case | Patient (age/sex) | Time to hypercalcemia onset | Peak calcium (mg/dL) | Complications | Management |
|---|---|---|---|---|---|
| Severe hypercalcemia complicating recovery of acute kidney injury due to rhabdomyolysis []6 | 23/male | 3 weeks | 17.1 | Acute kidney injury | Intravenous fluids, calcitonin, pamidronate, 1 session of dialysis with calcium-free dialysate |
| Bone scintigraphy of severe hypercalcemia following simvastatin-induced rhabdomyolysis []1 | 60/male | 1 month | 14.1 | Calcium deposition in multiple muscle groups (scintigraphy); required dialysis | Calcitonin, zoledronic acid, hemodialysis |
| Hypercalcemia complicated by rhabdomyolysis and acute kidney injury []7 | 57/male | 3 weeks | 13.3 | Acute kidney injury, hemodialysis, seizures, muscle calcifications | Intravenous fluids, denosumab |
| The silent surge: a case of rhabdomyolysis-induced hypercalcemia [present case] | 48/male | 6 weeks | 15.3 | Acute kidney injury, fungal peritonitis, compartment syndrome | Intravenous fluids with intravenous furosemide, followed by denosumab |