Werner Syndrome Masquerading as Type 2 Diabetes: A Diagnostic Odyssey Leading to Precision Medicine

22 August 2026 : Case report China

Challenging differential diagnosis, Unusual or unexpected effect of treatment, Rare disease

Aibibai Yusufu^{AEFG 1,2*}, Asiguli Adili^{EF 3,2}, Sheng Jiang^{AE 1,2}, Yihan Wei^{E 1,2}, Hailin Ma^{E 1,2}

DOI: 10.12659/AJCR.952718

Am J Case Rep 2026; 27:e952718

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Table 1 Laboratory investigations.

Test	Upon admission		Normal range
Test	Fasting	Postprandial	Normal range
PG	11.15 mmol/L	18.36 mmol/L
CP	1.58 ng/mL	3.09 ng/L
HbA1c	10.90%		4.8%–6.0%
TG	19.3 mmol/L		0.29–1.83 mmol/L
TC	8.40 mmol/L		2.8–5.7 mmol/L
KB	0.3 mmol/L		< 0.5 mmol/L
LA	1.3 mmol/L		0.7–2.2 mmol/L
ICA	(−)		(−)
IAA	(−)		(−)
ATA	(−)		(−)
GADA	(−)		(−)
T	3.37 ng/mL		4.94–32.01 ng/mL
LH	4.9 IU/L		0.57–12.07 IU/L
FSH	8.38 IU/L		2.64–13.13 IU/L
Abbreviations (alphabetical order): ATA, anti-tyrosine phosphatase antibody; CP, serum C-peptide; FSH, follicle-stimulating hormone; GADA, glutamic acid decarboxylase antibody; HbA1c, glycated hemoglobin A1c; IAA, insulin autoantibody; ICA, islet cell antibody; KB, ketone body; LA, lactic acid; LH, luteinizing hormone; PG, plasma glucose; T, testosterone; TC, total cholesterol; TG, triglycerides.

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