28 September 2026
: Case report 
Coexisting Postural Orthostatic Tachycardia Syndrome on Autonomic Reflex Testing in Functional Neurologic Disorder
Unusual clinical course, Challenging differential diagnosis
Sushmita Das
AEF 1, Sri Rama Narayana Yerraballa AEF 1, Priyanka Shekhawat AEF 1*
DOI: 10.12659/AJCR.953323
Am J Case Rep 2026; 27:e953323
Table 1 Diagnostic criteria for hypermobile Ehlers-Danlos syndrome (hEDS), adapted from the 2017 international classification.
| Criterion | Details |
|---|---|
| Criterion 1: generalized joint hypermobility | Beighton score: ≥ 5 in adults aged ≤ 50 yearsIf the Beighton score is 1 point below the age-specific cutoff, ≥ 2 positive historical hypermobility features may be used to satisfy criterion 1 |
| Criterion 2: ≥ 2 of the following | Feature A:Systemic connective tissue featuresExamples: soft or velvety skin; mild skin hyperextensibility; striae; piezogenic papule; hernia; dental crowding; high palate; mitral valve prolapse; aortic root dilationFeature B:Family history; first degree relative meeting criteriaFeature C:Musculoskeletal complications; chronic pain (> 3 months); recurrent joint dislocations; instability |
| Criterion 3: exclusion of alternative diagnosis | Must exclude other EDS subtypes; Marfan syndrome; Loeys-Dietz syndrome; skeletal dysplasia; neuromuscular disorders |