Combination of Multiple-Dose Activated Charcoal and Infusion Therapy That Led to Favorable Outcomes in Colchicine Poisoning: A Case Report

01 September 2026 : Case report Japan

Unknown etiology, Management of emergency care

Manabu Eiraku^{AB 1}, Kazuyuki Miyamoto^{E 1,2*}, Keisuke Suzuki

^{B 1}, Kazumasa Abe^{C 3}, Tatsuro Tamatsukuri^{D 3}, Asuka Kaizaki-Mitsumoto^{CDE 4}, Kazuki Kikuchi

^{B 1}, Masaharu Yagi

^{B 1}, Satoshi Numazawa

^{CD 4}, Kenji Dohi^{DE 1}

DOI: 10.12659/AJCR.953541

Am J Case Rep 2026; 27:e953541

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Table 1 Laboratory data on admission and serial values during hospitalization (h-PI = hours post ingestion).

Parameter	Admission (27 h-PI)	Day 2 6: 00 AM	Day 2 6: 00 PM	Day 3 6: 00 AM	Day 3 6: 00 PM	Day 4 6: 00 AM	Day 5 6: 00 AM
WBC (/μL)	10 800	13 900	12 100	14 000	14 400	13 100	11 300
Hb (g/dL)	15.4	14.8	13.8	14.1	14.5	14.6	14.4
Plt (×10/μL)	31.7	30.9	27.7	26.6	28.3	27.9	26.2
PT (%)	90	86	79	88	90	86	91
APTT (s)	30.1	29.2	41.0	29.4	32.3	32.5	31.0
Fibrinogen (mg/dL)	230	—	—	289	356	425	444
D-dimer (μg/mL)	0.50	0.47	0.59	0.56	0.74	0.92	1.03
T-Bil (mg/dL)	1.1	1.1	1.1	1.2	1.1	0.8	0.7
AST (U/L)	24	20	16	16	17	14	15
ALT (U/L)	22	18	16	16	15	14	16
LDH (U/L)	184	145	130	138	175	145	120
Lactate (mmol/L)	0.87	0.73	0.78	0.65	0.77	0.63	0.67
Creatinine (mg/dL)	0.58	0.65	—	0.53	—	0.56	0.61
BUN (mg/dL)	9.9	11.6	—	2.8	—	2.5	6.0
eGFR (mL/min/1.73 m)	149	131.5	—	164.5	—	154.8	141.0
Na (mEq/L)	136.3	140.3	138.5	136.3	136.7	138.1	138.8
K (mEq/L)	4.1	3.8	3.5	3.9	3.6	3.9	4.0
Cl (mEq/L)	102.6	101.4	104.2	102.1	103.0	105.1	105.7
Abbreviations: h-PI, hours post-ingestion; WBC, white blood cell count; Hb, hemoglobin; Plt, platelet; PT, prothrombin time; APTT, activated partial thromboplastin time; T-Bil, total bilirubin; AST, aspartate aminotransferase; ALT, alanine aminotransferase; LDH, lactate dehydrogenase; eGFR, estimated glomerular filtration rate. “—” indicates not measured at this time point.

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