26 September 2026
: Case report 
When A Fall Isn’t Just a Fall: Delayed Diagnosis of Acquired Hemophilia A in a Nonagenarian Patient
Mistake in diagnosis, Rare disease
Swati Gobhil BCDEF 1*, Arjun Khunger BCDEF 1, Prajeesh Kandoth Karerat BCDEF 1DOI: 10.12659/AJCR.954126
Am J Case Rep 2026; 27:e954126
Table 2 Coagulation mixing study results. Immediate testing of a 1: 1 mix of patient and normal pooled plasma resulted in an activated partial thromboplastin time (aPTT) of 31 seconds, whereas testing of the same mix after a 1-hour incubation at 37 °C resulted in an aPTT of 43 seconds, which indicates likely presence of a factor VIII inhibitor prolonging aPTT by 12 seconds upon incubation.
| Test | Result | Reference range |
|---|---|---|
| aPTT patient | 45 seconds | 22–35 seconds |
| aPTT normal pooled plasma | 27 seconds | 22–35 seconds |
| aPTT 1: 1 mixing immediate | 31 seconds | 22–35 seconds |
| aPTT 1: 1 mixing incubated | 43 seconds | 22–35 seconds |