Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

07 August 2020: Articles  Saudi Arabia

Colonic Polyps an Unusual Manifestation of Schistosomiasis

Challenging differential diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Rare disease, Educational Purpose (only if useful for a systematic review or synthesis), Rare coexistence of disease or pathology

Ali Mothanna Al-Zubaidi12ABCDEFG*, Galal Ahmed Bashanfer3BG, Mashhour H. Alqannas4BC, Abdullah Suliman Al Atawi5CF

DOI: 10.12659/AJCR.923177

Am J Case Rep 2020; 21:e923177

0 Comments

Abstract

BACKGROUND: Although reports of bilharizial colonic polyps are very rare in the literature, we report a case of a large rectal polyp as a manifestation of chronic intestinal bilharzia. A high index of suspicion in an endemic area is the key factor to avoid unnecessary medical interventions.

CASE REPORT: We report a case of a 24-year-old male patient who was married, born in Taiz North Yemen, and worked as a military soldier. He presented to our clinic with a complaint concerning intermittent lower abdominal pain and several months of rectal bleeding. A colonoscopy was performed at the Endoscopy Unit of King Khalid Hospital, Najran, Saudi Arabia on September 23, 2019 and results showed 2 large rectal polyps, (measuring 4×3 and 2×3 cm), located 10 cm from the anal verge, having wide bases and irregular surfaces that mimicked dysplastic polyps. Both polyps became elevated after a normal saline/methylene blue injection. An endoscopic mucosal resection was successfully performed with no immediate complications. The histopathology showed benign polyps due to Schistosoma-induced colonic infection.

CONCLUSIONS: It is very difficult and challenging to differentiate Schistosoma-induced colonic polyps from other colonic polyps even with an endoscopic evaluation; thus, a high index of clinical suspicion is required mainly in an endemic area, which may prevent the physician from ordering unnecessary interventions and thus avoid severe complications.

Keywords: colonic polyps, Schistosoma, Schistosoma mansoni, Colonoscopy, Rectal Neoplasms, Saudi Arabia, Schistosomiasis, young adult

Background

Schistosomiasis is one of the debilitating tropical diseases globally, and it is a major cause of morbidity and mortality in the Middle East, Asia, Africa, and South America.

Approximately 250 million people are infected, and 700 million people are at risk of infection. In more than 70 countries the infection is endemic with an estimated 660 million infections are concentrated in Africa, which accounts for 85% of the global at-risk estimated [1–3] Schistosoma can affect any site in the digestive tract, but the preferred site is the rectum while the sigmoid is rarely effected, and on occasion, it is found in the other parts of the large and small intestines. The polyp consists of a combination of a vascular neoformation and an inflammatory reaction to parasite eggs; worm can be found either dead or alive inside the polyp tissue [4] S. mansoni may be associated with the sexually transmitted disease as its eggs have been isolated from the condyloma acuminatum of patients with positive tests for human papillomavirus (HPV) in addition to human immunodeficiency virus (HIV) patients [5,6].

The objective of our study was to report a case of a Schistosoma-induced large rectal polyp in an immunocompetent young male, who presented with abdominal pain and bleeding from the rectum, and then was subjected to unnecessary invasive endoscopic management.

Case Report

HISTOPATHOLOGY:

The histopathology results showed an infectious polyp containing oval shape Schistosoma eggs with long sharp lateral spine (Figure 3) surrounding by granuloma (Figure 4) indicate chronicity of the infection. In addition, Schistosoma worms were found inside the polyp tissue (Figure 5). The patient received anti-helminthic treatment (praziquantel 40 mg/kg for 3 days) on an out-patient basis after which he improved during follow-up in the out-patient clinic after 3 months when he was asymptomatic.

MACROSCOPIC:

The macroscopic examination showed 2 polypoid soft tissue masses measuring 4×3×3 cm and 4×2×0.5 cm that were fixed in 10% formaldehyde. The cross-sectional surface was firm and whitish with an irregular white lining and superficial ulceration. The slide was stained with hematoxylin and eosin (H&E) and examined using an optical microscope.

MICROSCOPIC:

Microscopic sections revealed polypoid lesions lined by granulation tissue and partially by colonic epithelium. The stroma shows an eosinophil-rich granulomatous reaction surrounding many Schistosoma eggs (Figures 3, 4) and Schistosoma worms (Figure 5). No dysplasia or malignancy was seen.

Discussion

The 2 major species of Schistosomes commonly produce gastrointestinal diseases: S. mansoni and S. japonicum. The infection is usually acquired in childhood in an endemic area, such as the Middle East [7]. The World Health Organization (WHO) estimated that at least 229 million people required preventive treatment in 2018. The prophylactic treatment should be repeated over several years to reduce morbidity [8]. We describe a case of 2 large wide-base rectal polyps with irregular surfaces that mimicked dysplastic polyps that were completely removed endoscopically via an EMR. A histopathological examination confirmed that it was a case of benign polyp caused by a S. mansoni infection in a 24-year-old Yemeni male, who was most probably infected when he was an adolescent in his home country, in which he used to swim in dams and rain water streams. Most of the patients with schistosomiasis have mild to moderate disease, and only 5% to 10% will be severely infected [9]. There are no specific symptoms of colonic schistosomiasis, and its symptoms mimic other gastrointestinal problems, such as diarrhea, abdominal distension, lower abdominal pain, bleeding from the rectum, and altered bowel habits [10]. Intestinal diseases, especially in the colon, are mostly caused by S. mansoni as the most commonly implicated pathogen. The most common histopathological findings from colonic biopsies of patients are S. mansoni ova in the colonic mucosa with no or mild inflammatory cell infiltrates that correlate with the endoscopic appearance in most patients [10–12]. Patients may present with non-specific symptoms, such as lower abdominal pain, occasional diarrhea, and rectal bleeding. A differential diagnosis may include a variety of colonic diseases, such as inflammatory bowel disease, infectious colitis, and colorectal malignancies. There is a correlation between symptom frequency and infection intensity, and the spectrum of colonic schistosomiasis varies from diffuse proctocolitis to granulomatous disease or isolated polyposis [13,14]. As in our patient, all parts of the colon can be affected, but inferior mesenteric vein territory involvement in most of the cases indicates the infection most frequently involves the descending colon [13]. Intestinal Schistosoma rarely manifests as an intestinal obstruction caused either by intussusception of the ileocecal valve due to Schistosoma egg-induced fibrosis or a large polypoid mass causing luminal obstruction [14,15]. The studies concerning the pre-malignant risk potential of Schistosoma infection are limited and inconclusive with a limited causal relation between colorectal cancer and Schistosoma infection for both S. japonicum and S. mansoni [16,17].

Conclusions

It is very rare to encounter a Schistosoma infection that leads to formation of large colonic polyps manifested clinically as chronic abdominal pain and rectal bleeding in a young healthy individual. Endoscopically, it is very difficult to differentiate this type of polyp from other colonic polyps; thus, a high index of clinical suspicion is required mainly in endemic areas that may prevent the physician from performing unnecessary interventions and avoid catastrophic complications that may occur. As demonstrated in this case report, large rectal polyps manifested as rectal bleeding and an unnecessary invasive intervention was performed for this patient who could be treated medically once he was appropriately diagnosed.

References:

1.. Olveda DU, Li Y, Olveda RM, Bilharzia: Pathology, diagnosis, management and control: Trop Med Surg, 2013; 1; 135

2.. Elbatee HE, Emara MH, Zaghloul MS, Huge bilharzial polyp mimicking colon cancer: JGH Open, 2019; 4; 280-83

3.. Barsoum R, Esmat G, El Baz T, Human schistosomiasis: Clinical perspective: Review: J Adv Res, 2013; 4; 433-44

4.. Raso P, Sander EM, Raso L: Rev Soc Bras Med Trop, 2013; 46(2); 252-54

5.. Gholam P, Autschbach F, Hartschuh W, Schistosomiasis in an HIV-positive patient presenting as an anal fissure and giant anal polyp: Arch Dermatol, 2008; 144; 950-52

6.. Carneiro FP, Moraes MAP, Carneiro MV: Rev Bras Coloproct, 2007; 27; 207-9 [in Portuguese]

7.. Gryseels B, Polman K, Clerinx J, Kestens L, Human schistosomiasis: Lancet, 2006; 368(9541); 1106-18

8.. : Schistosomiasis, 2020 Available from: https://www.who.int/news-room/fact-sheets/detail/schistosomiasis

9.. Elliott DE, Schistosomiasis. Pathophysiology, diagnosis, and treatment: Gastroenterol Clin North Am, 1996; 25(3); 599-625

10.. Mohamed AR, Al Karawi MA, Yasawy MI, Schistosomal colonic disease: Gut, 1990; 31; 439-42

11.. Lamyman MJ, Noble DJ, Narang S, Small bowel obstruction secondary to intestinal schistosomiasis: Trans R Soc Trop Med Hyg, 2006; 100(9); 885-87

12.. Bosire F, Orwa I, Mwachir M, Parker R: Annals of African Surgery, 2018; 15(2); 81-85

13.. Cao J, Liu WJ, Xu XY, Endoscopic findings and clinicopathologic characteristics of colonic schistosomiasis: A report of 46 cases: World J Gastroenterol, 2010; 16(6); 723-27

14.. Meybehm M, Dworák O, Gugler R, Granulomatous colitis with pseudopolyp in schistosomiasis: Dtsch Med Wochenschr, 1989; 114(1); 19-22

15.. Mazigo H, Chandika A, Zinga M, Intestinal schistosomiasis associated with intussusception. a case report: Tanzan J Health Res, 2011; 13(2); 139-41

16.. Salim OE, Hamid HK, Mekki SO, Colorectal carcinoma associated with schistosomiasis. A possible causal relationship: World J Surg Oncol, 2010; 8; 68

17.. Li WC, Pan ZG, Sun YH: World J Gastroenterol, 2006; 12(37); 6077-79

In Press

Case report  Portugal

Bartter Syndrome Presenting as Arginine-Vasopressin Resistance: A Report of 2 Cases

Am J Case Rep In Press; DOI: 10.12659/AJCR.942872  

Case report  China (mainland)

Extended Left Hemihapatectomy with Right Hepatic Artery Reconstruction for Primary Hepatic Neuroendocrine N...

Am J Case Rep In Press; DOI: 10.12659/AJCR.943721  

Case report  Austria

Smoking-Associated Endotracheal Hair Growth: A Case Report on Tracheal Complications

Am J Case Rep In Press; DOI: 10.12659/AJCR.943909  

Case report  Japan

Virtual Reality-Guided Simulation for Percutaneous Coronary Intervention in a Patient with Anatomical Anoma...

Am J Case Rep In Press; DOI: 10.12659/AJCR.944485  

Most Viewed Current Articles

07 Mar 2024 : Case report  USA 38,124

Neurocysticercosis Presenting as Migraine in the United States

DOI :10.12659/AJCR.943133

Am J Case Rep 2024; 25:e943133

0:00

10 Jan 2022 : Case report  Germany 31,073

A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...

DOI :10.12659/AJCR.935263

Am J Case Rep 2022; 23:e935263

19 Jul 2022 : Case report  Saudi Arabia 17,693

Atlantoaxial Subluxation Secondary to SARS-CoV-2 Infection: A Rare Orthopedic Complication from COVID-19

DOI :10.12659/AJCR.936128

Am J Case Rep 2022; 23:e936128

23 Feb 2022 : Case report  USA 17,607

Penile Necrosis Associated with Local Intravenous Injection of Cocaine

DOI :10.12659/AJCR.935250

Am J Case Rep 2022; 23:e935250

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923