Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

15 August 2020: Articles  USA

A Case of Spontaneous Pneumothorax 21 Days After Diagnosis of Coronavirus Disease 2019 (COVID-19) Pneumonia

Diagnostic / therapeutic accidents

Ashraf Abushahin1ABCDEF*, John Degliuomini2E, Wilbert S. Aronow3ADEF, Thomas Newman1ABDE

DOI: 10.12659/AJCR.925787

Am J Case Rep 2020; 21:e925787

0 Comments

Abstract

BACKGROUND: At the end of 2019, coronavirus (SARS-CoV-2) was recognized as the cause of a cluster of pneumonia cases in Wuhan, a city in China. There are numerous complications associated with COVID-19 infection, such as acute respiratory distress syndrome, renal failure, circulatory shock, and multi-organ failure. Spontaneous pneumothorax following COVID-19 pneumonia is an extremely rare complication.

CASE REPORT: We report the case of a 49-year-old man with a past medical history of type 2 diabetes mellitus with an initial presentation of cough, shortness of breath, and fever. He was diagnosed with COVID-19 pneumonia and rapidly deteriorated on the day of admission, requiring initiation of mechanical ventilation. The patient recovered clinically and was discharged home. He returned 21 days after discharge with a spontaneous pneumothorax.

CONCLUSIONS: Spontaneous pneumothorax is a rare complication after apparent recovery from COVID-19 pneumonia. It is imperative that treating physicians are aware of this complication in order to recognize it early and treat it promptly.

Keywords: COVID-19, Pneumothorax, SARS Virus, Pandemics, Betacoronavirus, COVID-19, Chest Tubes, Coronavirus Infections, Diabetes Mellitus, Type 2, Dyspnea, Middle Aged, Pneumonia, Viral, SARS-CoV-2, Tomography, X-Ray Computed

Background

OBJECTIVE:

To make physicians aware of a spontaneous pneumothorax as a possible complication post COVID-19 pneumonia.

Case Report

Our patient was a 49-year-old man who presented to the hospital with worsening shortness of breath, dry cough, and chest tightness for 3 days. His past medical history was significant for type 2 diabetes mellitus. His initial vitals were as follows: temperature 39.6°C, blood pressure 108/79 mmHg, heart rate 114 beats per minute, respiratory rate 30 breaths per minute, and oxygen saturation of 86% on room air. Laboratory tests were notable for leukocytosis (i.e., white blood cell count of 12.9×103/mcl). The chest x-ray showed bilateral infiltrates, mostly prominent in the lower lobes (Figure 1). The screening was negative for multiple respiratory pathogens, including Influenza A, Influenza B, Respiratory Syncytial Virus, Adenovirus, and Human Parainfluenza Virus. The diagnosis of COVID-19 was confirmed by real-time reverse transcriptase-polymerase chain reaction (RT-PCR) testing from nasopharyngeal swab (Cepheid/GenXpert system). The patient was placed on nasal cannula 6 L/min, which only slightly improved his oxygen saturation to 88%. He was subsequently intubated in the intensive care unit due to worsening respiratory failure. The ventilator mode was volume-controlled and the initial settings were as follows: Tidal Volume 380 ml, Respiratory Rate 22, FIO2 80% and Positive End Expiratory Pressure (PEEP) 14. He was treated with piperacillin/tazobactam, vancomycin, azithromycin, and hydroxychloroquine. The patient was intubated for 8 days, and after much improvement, he underwent a successful extubation. During his stay in the intensive care unit, he did not require any other invasive procedures or central lines. After an additional 5 days of supportive care on the medical floor, the patient was discharged home in stable condition.

Twenty-one days after discharge, the patient returned to the emergency room because of sudden onset of shortness of breath. He reported no history of trauma. A large left-sided pneumothorax was found on the chest x-ray (Figure 2A). The patient was hemodynamically stable, and his shortness of breath improved after insertion of a pigtail chest tube (Figure 2B). Following the chest tube insertion, a CT scan of the chest without contrast was completed, showing significant residual bilateral pulmonary infiltrates (Figure 3). The patient was eventually discharged home.

Discussion

The spectrum of symptomatic infection with COVID-19 pneumonia ranges from mild to critical. Some patients rapidly develop acute respiratory distress syndrome (ARDS), as well as other serious complications, including renal failure and circula-tory shock [5]. Developing a spontaneous pneumothorax due to COVID-19 pneumonia is rare [5, 6] and the exact pathogenesis is not yet explained. Our patient had a pneumothorax, which occurred after an apparent clinical recovery of COVID-19 pneumonia and without any known precipitating factor or trauma.

Pneumothorax is defined as the presence of air in the pleural cavity. Risk factors for pneumothorax include male sex, smoking, mechanical ventilation, trauma, and the presence of underlying lung disease such as emphysema, cystic fibrosis, necrotizing pneumonia, severe asthma, and lung malignancy [8]. Pneumothorax can be classified as spontaneous (no obvious precipitating factor identified) and nonspontaneous.

Our patient developed spontaneous pneumothorax 21 day after apparent clinical recovery. Most authors believe that subpleural blebs are always the cause of spontaneous pneumothorax [9].

In our patient, there was no bulla or pneumothorax observed in the chest x-ray during initial presentation, after intubation, or at the time of discharge. However, mini-blebs could have formed due to the inflammation, and later ruptured causing the pneumothorax [10]. We also hypothesize that ischemic breakdown of the alveolar wall secondary to micro-thrombi, a feature of this disease [11], could have led to leakage of air into the pleural space. Lastly, the intense cough could have induced rupture of the alveolar wall by increasing the intra-alveolar pressure, called the Maclin effect.

Conclusions

A spontaneous pneumothorax can occur following recovery from COVID-19 pneumonia. It is important that physicians treating COVID-19 pneumonia consider pneumothorax when COVID patients develop sudden deterioration in their respiratory status.

References:

1.. https://www.who.int/emergencies/diseases/novel-coronavirus-2019

2.. Richardson S, Hirsch JS, Narasimhan M, Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area: JAMA, 2020; 232(20); 2052-59

3.. Dai H, Zhang X, Xia J, High-resolution chest CT features and clinical characteristics of patients infected with COVID-19 in Jiangsu, China: Int J Infect Dis, 2020; 95; 106-12

4.. Zhao X, Liu B, Yu Y, The characteristics and clinical value of chest CT images of novel coronavirus pneumonia: Clin Radiol, 2020; 75(5); 335-40

5.. Chen N, Zhou M, Dong X, Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study: Lancet, 2020; 395(10223); 507-13

6.. Sun R, Liu H, Wang X, Mediastinal emphysema, giant bulla, and pneumothorax developed during the course of COVID-19 pneumonia: Korean J Radiol, 2020; 21(5); 541-44

7.. Carod-Artal FJ, Neurological complications of coronavirus and COVID-19: Rev Neurol, 2020; 70(9); 311-22

8.. Noppen M, Spontaneous pneumothorax: Epidemiology, pathophysiology and cause: Eur Respir Rev, 2010; 19(117); 217-19

9.. Light RW, Management of spontaneous pneumothorax: Am Rev Respir Dis, 1993; 148; 245-48

10.. Schramel F, Meyer CJ, Postmus PE, Inflammation as a cause of spontaneous pneumothorax and emphysema-like changes: Results of bronchoalveolar lavage: Eur Respir Rev, 1995; 8(Suppl. 19); 397s

11.. Connors JM, Levy JH, COVID-19 and its implications for thrombosis and anticoagulation: Blood, 2020; 135(23); 2033-40

SARS-CoV-2/COVID-19

30 November 2022 : Case report  Gabon

Severe COVID-19 in 2 Kidney Transplant Patients in Gabon

Am J Case Rep In Press; DOI: 10.12659/AJCR.938003  

23 November 2022 : Case report  Grenada

Mepolizumab as a Potential Protective Factor of COVID-19 Mortality: A Case Report of Chronic Bronchitis and...

Am J Case Rep In Press; DOI: 10.12659/AJCR.938450  

In Press

02 Dec 2022 : Case report  Portugal

A 54-Year-Old Woman with Papillary Thyroid Carcinoma Associated with Secondary Amyloid Goiter and Thyroid L...

Am J Case Rep In Press; DOI: 10.12659/AJCR.938156  

02 Dec 2022 : Case report  Saudi Arabia

A 14-Year-Old Saudi Boy with Gynecomastia, Cushing Syndrome, Large-Cell Calcifying Sertoli Cell Tumor of th...

Am J Case Rep In Press; DOI: 10.12659/AJCR.937404  

01 Dec 2022 : Case report  China (mainland)

Ureterolithiasis in Human Immunodeficiency Virus (HIV) Patients Treated with Single-Use Ureteroscope: A Cas...

Am J Case Rep In Press; DOI: 10.12659/AJCR.938608  

01 Dec 2022 : Case report  Saudi Arabia

Ancient Schwannoma: Case Report of an Unusual Entity in an Unusual Oral Location

Am J Case Rep In Press; DOI: 10.12659/AJCR.938335  

Most Viewed Current Articles

13 Jul 2022 : Case report  USA

Whistling Scrotum: An Unusual Presentation of Pneumomediastinum in the Setting of an Open Scrotal Wound

DOI :10.12659/AJCR.936441

Am J Case Rep 2022; 23:e936441

23 Feb 2022 : Case report  USA

Penile Necrosis Associated with Local Intravenous Injection of Cocaine

DOI :10.12659/AJCR.935250

Am J Case Rep 2022; 23:e935250

06 Dec 2021 : Case report  Brazil

Lipedema Can Be Treated Non-Surgically: A Report of 5 Cases

DOI :10.12659/AJCR.934406

Am J Case Rep 2021; 22:e934406

17 Feb 2022 : Case report  Oman

Myocarditis, Pulmonary Hemorrhage, and Extensive Myositis with Rhabdomyolysis 12 Days After First Dose of P...

DOI :10.12659/AJCR.934399

Am J Case Rep 2022; 23:e934399

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923