01 August 2022: Articles
Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Rare disease, Educational Purpose (only if useful for a systematic review or synthesis)Elias Antoniades1ABEF*, Angeliki Cheva2BCF, Jannis Constantinidis3BCD, Evangelia Kalloniati4ABF, Ioannis Patsalas1ABF
Am J Case Rep 2022; 23:e935876
BACKGROUND: Sinonasal undifferentiated carcinomas (SNUC) are highly malignant and rare lesions. Therapeutic efforts often provide frustrating results. Their course is characterized by indolent progression, until it culminates in extensive local infiltration of adjacent anatomical structures or cervical lymphadenopathy in approximately one-third of patients upon admission. It most frequently affects males, with a sex ratio of 3: 1. The age at manifestation tends to be about 40-50 years.
CASE REPORT: We report the case of a 41-year-old man with intracranial expansion of SNUC. Two previous sinus surgeries were performed endoscopically because the lesion at that moment was exclusively located endonasally. Within the last few months, he had been having persistent headaches. Magnetic resonance imaging (MRI) revealed an anterior cranial fossa lesion. Therefore, he underwent a bifrontal craniotomy and excision of the space-occupying lesion (SOL). The osseous defect of the skull base was covered with a titanium mesh. Finally, we performed a duraplasty using a pericranial flap and fat tissue taken from his abdomen. Postoperatively, his wound was dehisced. We proceeded then to a frontal craniectomy with surgical debridement, subgaleal empyem and epidural abscess removal, and copious irrigation with oxygen peroxide. Enterococcus spp. were isolated from pus cultures. Despite receiving bacteria-focused antibiotics, he unfortunately developed sepsis and died. The histopathologic findings revealed a SNUC, which is the criterion standard for diagnosis.
CONCLUSIONS: Multimodal treatment offers the best prognosis to patients with SNUC. Combined operations by otolaryngologists and neurosurgeons provide the necessary radicality. There is high risk of wound healing disorders, especially when local irradiation had been administered.
Keywords: Epidural Abscess, Sepsis, Sinonasal Undifferentiated Carcinoma, Adult, Carcinoma, Combined Modality Therapy, Humans, Male, Maxillary Sinus Neoplasms, Skull Base
Undifferentiated carcinoma of nasal sinuses constitutes a very rare and malignant tumor that is often frustrating to treat . It progresses indolently, until it develops extensive local infiltration of proximal structures  or with cervical lymphadenopathy in 10–30% of patients upon admission . The initial clinical signs usually show benign manifestation, such as nasal congestion, headache, nose-bleed, or facialgia; visual deficits, periorbital edema, exophthalmos, and cranial nerve paralysis may also appear . There is documented to be more common in males, with a 3: 1 sex ratio. They usually appear in patients in their forties, ranging from age 8 to 85 years . When these carcinomas are diagnosed they are usually associated with progressive deterioration and general poor prognosis .
Here, we report the case of a 41year-old man with intracranial expansion of sinus nasal undifferentiated carcinoma (SNUC). Two endoscopically performed sinus surgeries were performed and the lesion was exclusively located endonasally.
A 41-year-old man was admitted to our Neurosurgical Clinic owing to refractory frontally located headaches within the last 7 days, and he had vomiting and nuchal pain. His past medical history at an ear-nose-throat (ENT) clinic included a Draf IIa frontal sinusotomy 6 months before, where a SNUC lesion was removed. The malignancy was located at an adjacent nasoethmoid site and there was no lymphadenopathy or metastases (T2N0M0).
Owing to local recurrence and bony erosion of the cribriform plate without intracranial extension, he underwent a Draf IIb procedure 2 months afterwards. Duraplasty and endonasal flap mobilization was performed due to cerebrospinal fluid (CSF) leakage.
During the last hospitalization he also had an acute coronary incident that necessitated emergent coronography and stenting. He had also received 3 cycles of cisplatin combined with 60 Grays (Gy) of intensity modulated radiotherapy (IMRT) over a 6-week period.
During the present admission, the initial radiologic control with head computed tomography (CT) revealed a hyperdense anterior cranial fossa space-occupying lesion (SOL) on his left side (Figure 1A, 1B). The SOL was abutting the ethmoidal and frontal bones and eroded inner orbital wall and had perifocal edema. We stopped his antithrombotic treatment for 1 week and then performed magnetic resonance imaging (MRI). The tumor had high intensity on T1 images and was enhancing after contrast medium administration. On T2 sequences, it was isointense and its dimensions were 1.7×2 cm. It was infiltrating the dura propria of the left frontobasis and left orbital gyri. Vasogenic edema was present on fluid-attenuated inversion recovery (FLAIR) sequences, extending to the left frontal lobe up to the ipsilateral frontal ventricular horn. Therefore, we proceeded to the third operation (Figure 2A–2E). He underwent a bifrontal craniotomy with excision of the SOL via an intradural plane. The osseous defect of the skull base was covered with titanium mesh. We also performed a duraplasty using a pericranium flap and a fat graft taken from the abdomen (Figure 3).
Ten days after the operation, he had fever and pus egression from the wound region, but his neurological status was intact. The new CT showed subgaleal empyem and epidural abscess in the surgical area (Figure 4). We proceeded to a frontal craniectomy with surgical debridement, removal of osseous flaps, and copious irrigation with oxygen peroxide. Two retractable duplicated sheets of iodoform gauze were left as drainage frontal-bilaterally.
In pus cultures, we isolated
The histological examination of the samples revealed medium-size cuboidal cells, with round and oval nuclei with nucleoli, a high nuclear/cytoplasmic ratio, moderate to increased pleomorphism and atypia, and increased mitotic activity. They are densely arranged with extended necrosis. Glial cells were with GFAP stain and were located at the margin of the tumor specimen. Immunohistochemical stains were performed. All the neoplastic cells were strongly positive for keratins CK7 and CK8/18 (Figure 5). Due to the morphology of the neoplastic cells and according to the current immunophenotype, our diagnosis was compatible with SNUC.
SNUC arises from the olfactory epithelium of the sinonasal mucous membrane and shows abnormal intermediate-sized cells forming niduses or lamellae with necrosis, vascular permeation, and mitoses . SNUC potential malignancies for these structures are carcinomas of the squamous layer, neuroepithelial carcinoma, carcinoid, malignancies of lymphatic tissue, melanocytes and skeletal muscle cancer, and lymphoepithelioma . Histopathology and immunohistochemical assessment are the criterion standard for diagnosis .
Rosenthal et al  estimated the overall rate of newly diagnosed cases at 0.00002% and the 5-year OS rate at 35%, which is worse than for neuroendocrine sinonasal tumors. Older age at diagnosis is associated with shorter survival. The cut-off age with worsening prognosis was 60 years. Patients older than 70 years showed 2.5 times higher mortality rate . Cervical metastases, distant dissemination, lesions with mostly undifferentiated cells, and subtotal resection are associated with worse prognosis . Kadish  introduced a new scale to assess the extension of SNUC; Kadish stage C corresponds to infiltration of the orbit, skull base, or cerebral parenchyma .
Immunohistochemically, it is positive for cytokeratin, mixed positive/negative for epithelial membrane antigen (EMA) or neuron-specific enolase, and negative for S-100 protein .
In poorly undifferentiated carcinomas, deletion of SMARCB1 and SMARCA4 genes at the SWI/SNF complex has been proposed to constitute a pathognomonic marker of these neoplasms .
Amigay et al  studied 10 SNUC specimens and all tumors had complete deletion of the tumor suppressor gene SMARC4 and limited expression of SMARCB1/INI1, and all tumors had the classic positive pankeratin stain in immunohistochemistry. In their most recent studies, they focused on the detection of IDH2 mutations as the common feature of the group . These facts indicate that these neoplasms are a rather homogeneous group, which warrant a tailored approach.
A case series by Miyamoto et al  found survival over 5 years despite tumors advancing intra-cranially/orbitally. This suggested that extension itself had no effect on survival and that long-term survival was better with aggressive treatment.
Chambers et al  reported that resection alone had an overall advantageous effect on prognosis, with an HR of 0.73 (95% CI, 0.52–1.02). On the other hand, Kim and associates  reported a series of 8 patients treated within a period of 10 years, who had not received combined therapy. Consequently, they had poor outcome at 12-month follow-up, and only 2 out of 8 patients were alive and tumor-free.
Radiation alone showed a relative overall survival advantage . Thus, approaches employing a schema of resection, irradiation, and chemotherapy are the mainstay of SNUC treatment [3,19].
Regarding the utility of chemotherapy, it seems that SNUC responds well to it both before and after surgery or irradiation [3,18]. Tumors with undifferentiated cells may not have such an adverse cell proliferation and thus tend to respond better to such treatment . Chemotherapy can also reduce a lesion’s apposition in regions proximal to regions with critically low radiation threshold (eg, optic nerves), thus improving the outcomes [3,20].
A meta-analysis by Morand et al  found that SNUC appeared to be a chemosensitive tumor presenting most commonly to males and that surgery alone was not as effective as combined treatment. They estimated the 2-year local recurrence rate was 27% and 16% of patients had metastatic lymphadenopathy .
Regimens of either cyclophosphamide, vincristine and doxorubicin, or etoposide and cisplatin are usually administered. The 2- and 5-year OS rates were 47–65% and 37–43%, respectively .
Concerning irradiation, no strict guidelines exist. Christopherson et al  treated 23 patients with doses greater than 62.4 Gy and reported cause-specific survival. Doses varying from 50 to 65 Gy are now recommended due to a probable dose-response relationship. This result may also encourage the use of IMRT, which allows higher doses and avoids negative effects, such as retinopathy .
Gorelick et al  published a case series of 4 patients treated multimodally with chemotherapy, radiotherapy, and aggressive skull base surgery to the anterior cranial fossa. Three of the 4 patients died due to their disease approximately 15 months after diagnosis. The 1 survivor developed intracranial disease 2 years after diagnosis.
Orlandi et al  stated that a multimodal treatment strategy with induction chemotherapy provides longer overall survival (OS) and when there was recurrence, early surgery offered a survival benefit compared to stand-alone chemotherapy .
Xu et al  published a meta-analysis of 160 patients, of whom only 20 were treated by them. The survival rates at 1, 3, and 5 years were 51.2%, 19.45, and 6.25%, respectively . The period of time within at least half of the patients had survived was only 12.7 months. Only 39% of the patients underwent combined treatment with surgery and either chemotherapy or radiotherapy. Using Cox regression analysis, Xu et al  found a prognosis benefit related to combined therapeutic methods (
Reiersen et al  aggregated 167 cases to provide robust evidence favoring multimodality treatment. Patients receiving combined treatment had increased chances of survival, rating 260%, compared to stand-alone surgery.
Chambers et al  reported that surgery, irradiation, and chemotherapy combined provide prognostic benefits in cases of disease progression, compared use of a single method (
Optimized surgical techniques incorporating craniofacial approaches  and endoscope application to the skull base areas  have contributed significantly to this evolution over the last 40 years . Radiosurgery to the skull base may further improve survival, especially when total resection is not feasible .
As far as the type of surgery is concerned, Hanna et al  had conducted a retrospective study concerning 120 patients with sinonasal malignancies. They concluded that an endoscopic approach combined with craniotomy enables larger dura excision and better vascularization in the meningeal flap before high-dose radiation therapy . They also found that disease recurrence and OS were not significantly different between use of endoscopic resection alone versus endoscopic resection plus craniotomy .
Donald et al  described a series of 13 patients with skull base erosion, the majority of whom had extensive intra-calvarial and extracranial dissemination. No distant or cervical metastases had been reported upon presentation. The majority of the patients had undergone classical lateral rhinotomies, anterior maxillary ostectomies, or a medial maxillectomy along with a low anterior craniotomy. Seven patients died within 20 months after treatment. Survival at 2 years and beyond was 57%. Their tactic was intracranial/extracranial resection and postoperative irradiation, which they also advocate in their conclusions . Twenty months is considered the critical time after which multimodal treatment is considered successful .
Pradeep et al  published a case report of a male patient with an extra-axial lesion emerging from the ethmoidal sinus and intracranial extension into the frontal lobes with perifocal edema. The patient had left anopsia and anosmia. They excluded the presence of abdomen and thorax metastases with ultrasound (USG) of the abdomen and chest X-ray, and performed bifrontal craniotomy and fronto-orbital osteotomy with gross total resection of the lesion. The frontal sinus was cranialized and a pericranial flap was used as sealant. Bone reconstruction was performed with titanium plates and screws. At 1-year follow-up, the patient was alive.
Prasad et al  reported a 43-year-old man with bifrontal headache and nasal obstruction within the last 3 months. He was neurologically intact. In radiological examination, SOL was depicted in frontobasal and ethmoidal region and was attached to the medial wall of the left orbit. A tumor and its osseous apposition surfaces were removed. The frontal sinus was cranialized and the dura was repaired. The patient developed ipsilateral impairment of all cranial conjugates within the first week in the context of Garcin syndrome.
Hofer et al  presented a 62-year-old woman with nasal constipation on the right side and anosmia. Physical examination revealed a glazed, hemorrhagic SOL of her right nasal cavity and right nasopharynx extending contralaterally. Radiologic examination showed a tumor arising in the right nasal sinuses eroding the right lamina cribrosa and the posterior wall of the right frontal sinus. The tumor was near the frontal lobe, olfactory and optical nerves and infiltrated the meninges. After obtaining a specimen that confirmed the diagnosis, the patient was operated on both transnasally and via open craniotomy.
Yeung et al  retrospectively evaluated 17 patients who had local sinonasal malignancy progression. All patients were previously operated on and had also received chemotherapy and radiotherapy. The authors reported that they had achieved complete resection and the median progression-free survival was 24 months, whereas the median OS was 60 months. They found that salvage surgery was also an effective treatment.
Surgeons who strive to achieve radicality should consider the physiological dysfunction of the nasal cavity in malignancies. First of all, mucociliary clearance is impeded. In chronic inflammation states such as chronic rhinosinusitis, this phenomenon has been widely studied and is reported to reduce ciliary beat frequency and alterations in mucosal viscosity. Ciliary frequency is related to many factors like temperature, hormones, pH alterations, stress, and neurotransmitters. Mechanical factors such as pressure exerted on the cilia also induce their motility . In addition, plasma exudation and its flow across epithelial cells constitute a second protective mechanism that not only mechanically removes pathogens, but also contains immunoglobulins. Its production is attributed to the cyclic obstruction and decongestion of the nasal venous capillaries . Presumably, this procedure is also less effective in case of malignancies.
Yin et al  evaluated the mucociliary transport rate of 66 patients who had undergone IMRT over a period of 12 months. Utilizing multiple regression analysis, they found that the nasal radiation dose was an independent factor impairing mucociliary function, and they determined the tolerance threshold of radiation as 37 Gy .
Radical resections, on the other hand, reducing inferior turbi-nate mucosa, lead to decreased heating and humidification of the nasal cavity and thus share an increased risk of massive nasal desiccated discharge. Therefore, extension of the nasal airway and sinuses should be avoided .
Consequently, the consistency of the upper respiratory microbiome may alter after radiotherapy  and FESS procedures . This fact combined with the distorted anatomy may result in serious infections and wound healing disorders.
Multimodal treatment is the standard of medical care for SNUC and provide prognostic benefits. Joined skull base procedures from both ENT and neurosurgeons achieve the necessary radicality, especially in cases of intracranial extension. However, refractory postoperative infections and wound healing disorders should be expected as a result of this therapeutic approach.
FiguresFigure 1.. (A) CT scan of head with contrast medium axial slice: Infiltration of left frontal lobe. (B) Coronal slice: Impaired endonasal structures due to previous surgeries. Intracranially extended SNUC-perilesional edema. Red arrow: Lesion arising from ethmoidal cells and infiltrating dura matter. Figure 2.. (A) T1-weighted sequence: Contrast medium enhancing lesion arising from ethmoidal cells. Red arrow indicates the lesion. (B) T1-weighted sequence: Intracranial expansion of the lesion adjacent to inner orbital wall and left orbital gyri. Red arrow indicates the lesion. (C) T2-weighted sequence: Isointense tumor abutting ethmoidal bone. Red arrow indicates the tumor. (D) T2-weighted sequence: Infiltration of left orbital gyri; arachnoidal spaces are not depicted due to parenchyma’s edema. Red arrow indicates the tumor. (E) FLAIR sequence: Vertical extension of vasogenic edema up to the ipsilateral frontal ventricular horn. Red arrow indicates the edema. Figure 3.. CT scan of head, coronal slice: Postoperative control-tumor resection and titanium mesh for skull base reconstruction. Red arrow: Titanium mesh covering upper nasal and (partially) orbital wall defect. Figure 4.. CT scan with contrast medium: Axial slice-subgaleal empyema and epidural abscess-no parenchymal infectious collection. Red stars: Subcutaneous fluid collection with heterogeneous contrast enhancement. Figure 5.. (A) H-E x100 Cuboidal cells with increased nuclear-cytoplasmic ratio. (B) H-E ×400A Round and oval nuclei with nucleoli and moderate to increased pleomorphism and atypia. (C1) H-E ×100 densely arranged neoplasmatic cell with extended necrosis. (C2) GFAP ×400 glial cells lie at the margin of tumor specimen. (D1). CK7 ×100 cells positive in CK7 stain. (D2) CK 8/18 ×200 cells positive in CK8/18 stain.
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