03 September 2024: Articles
Rare Right Ventricular Calcified Amorphous Tumor Mimicking Malignancy: A Case Report
Challenging differential diagnosis, Rare disease
Ka Chun Lu1BEF, Cuixian Xie2AB, Jie Chen3BCD, Zhongsheng Kuang4BCD, Rui Peng5AG*DOI: 10.12659/AJCR.943908
Am J Case Rep 2024; 25:e943908
Abstract
BACKGROUND: Cardiac calcified amorphous tumor (CCAT), a peculiar and uncommon non-neoplastic cardiac lesion, was initially characterized by Reynolds and colleagues in the medical literature in 1997. This distinctive entity is hallmarked by its unique feature of pedunculated and diffused calcifications, primarily infiltrating the cardiac structures, with a predilection for the mitral valve annulus initially, followed in sequence by the right atrium, right ventricle, left atrium, left ventricle, and tricuspid valve annulus. The nature of CCATs, despite being benign, poses diagnostic dilemmas, as they frequently masquerade as malignant tumors due to their clinical presentations, which resemble those caused by potential complications such as obstructive masses and thromboembolic events.
CASE REPORT: A 50-year-old man presented to our hospital with shortness of breath. He had been short of breath for more than 5 years after repeated activities. Transthoracic echocardiography showed a mobile high echogenic mass from the middle of the right ventricular wall and pericardial effusion and right heart insufficiency. The electrocardiogram (ECG) results demonstrated a sinus rhythm, complete right bundle branch block, and T-wave alterations. Additionally, the chest computed tomography (CT) scan revealed a slightly enlarged heart with a lack of density and calcification in the right ventricle. He had an uneventful postoperative recovery after the resection of the cardiac tumor. The mass had not continued to grow when we compared it with preoperative cardiac color doppler echocardiography, after 3 months follow-up.
CONCLUSIONS: CCAT is a rare non-neoplastic cardiac entity. Diagnosis of CCAT poses a challenge due to the absence of distinct clinical features and its frequent misidentification as a malignant tumor mimic. Surgical resection serves as the sole treatment for symptom relief.
Keywords: Thoracic Surgery, Heart Diseases, Pathology, Clinical
Introduction
Cardiac calcification amorphous tumor (CCAT) is a non-neo-plastic intracardiac mass. It was originally described in 1997 by Reynolds et al [1], as an intracavitary mass with microscopic features of calcification and amorphous fibrinous material. The most common site is the mitral annulus followed by the right atrium (RA), right ventricle, left ventricle (LV), left atrium, and the tricuspid annulus [2]. As the clinical symptoms of CCAT resemble those of malignant tumors, including obstruction- or embolism-related symptoms, CCAT is often misdiag-nosed as a malignant cardiac tumor. We report a case of a 50-year-old man with a CCAT of the right ventricle, which underwent surgical excision.
Case Report
A 50-year-old man presented to our hospital with shortness of breath; he had been experiencing shortness of breath for more than 5 years after repeated activities. The Antibodies against Extractable Nuclear Antigens (anti-ENA) antibody spectrum test came back negative. The electrocardiogram (ECG) results demonstrated a sinus rhythm, complete right bundle branch block, and T-wave alterations. Additionally, the chest computed tomography (CT) scan revealed a slightly enlarged heart with a lack of density and calcification in the right ventricle. Admission examination revealed a 3/6 diastolic rumbling murmur that could be heard in the apical area, and moderate edema of both lower extremities. Blood examination results revealed brain natriuretic peptide (BNP) of 672 pg/mL (normal values range from 0–100 pg/mL). Transthoracic echocardiography showed enlargement of the right atrium and right ventricle, secondary right ventricular outflow tract obstruction, severe tricuspid regurgitation, and a mobile high echogenic mass from the middle of the right ventricular wall (Figure 1A). Bilateral lower extremity venous ultrasound showed local lumen thrombosis of the intermuscular vein of the right calf and abnormal blood flow spectrum of the remaining lower extremity veins, indicating the possibility of right heart insufficiency. We resected the mass surgically when the patient was stable.
During the operation, the right atrium and right ventricle were significantly enlarged. There was increased pulmonary artery return, and no terminal closure of the cardiac arterial ductus was seen on exploration after incision of the right ventricle. A stone-like mass was seen from the root of the right ventricular papillary muscle to the outflow tract (about 6×2 cm), with calcification and adhesion in the root. No thrombosis or other masses were seen (Figure 1B). Because the mass was too close to the root of the papillary muscle of the tricuspid valve, the structure of the tricuspid valve would be directly affected if the mass were to be removed. Therefore, the calcified tissue could only be partially removed. The postoperative course was uneventful. Pathologic examination of the excised mass revealed a calcified amorphous tumor (CAT). This amorphous tumor was composed of fibrin wrapped in dense calcifications; inflammatory cells and malignant cells were not observed (Figure 2A, 2B). The patient experienced an uneventful recovery following the surgical procedure. Upon comparison with preoperative cardiac color Doppler echocardiography after a 3-month follow-up period, there was no further growth noted in the mass (Figure 2C, 2D).
Discussion
CCAT was first proposed in 1997 [1]. It was first considered to be calcified thrombosis, but then was considered to be a rare benign primary tumor. However, the origin and etiology of CCATs remain unclear. According to Hemptinne’s systematic report [2], a CCAT can occur in any heart cavity or valve, but is seen predominantly on the mitral valve or annulus, in the right atrium, or in the right ventricle. As with other cardiac tumors, difficulty breathing, syncope, and embolism-related symptoms are the main symptoms of the CCAT [3], but the specificity of these symptoms is very low. These symptoms of CCAT can also result from thrombi, emboli, and other cardiac tumors.
CT scans typically reveal CCATs as irregular masses with varying degrees of calcification, either partially or diffusely, that are notably prevalent in the left ventricular chamber [4]. A distinguishing feature of CCAT is lack of enhancement when imaged with contrast medium on CT scans. Furthermore, these masses are not known to exhibit fluorodeoxyglucose (FDG) up-take in positron emission tomography combined with computed tomography (PET/CT) examinations, adding to their distinct radiological characteristics [5,6].
There have so far been limited data on the pathophysiology, treatment, and prognosis of CATs, although an association between thrombosis-induced factors and CCAT has been reported [1]. A link between CAT and end-stage kidney disease is thought to be associated with calcium homeostasis mechanism function disorder [3]. The majority of CATs are seen in association with valvular heart disease, end-stage renal disease, mitral annular calcification (MAC), or diabetes mellitus [2].
These primary cardiac tumors are rare; the most common benign cardiac tumor is myxoma [7], which is easily confused with CCAT. Myxoma can occur in any heart cavity, but, when present, is always located in the left atrium, and typically arises from the foramen ovale [8]. Myxoma should be considered in the differential diagnosis of CCAT. Myxomas are neoplasms of multipo-tent mesenchymal cells in the subendocardial tissue [9], can be round or polypoid, and are often gelatinous [10]. The main distinction between myxoma and CCAT is that myxoma can enhance on late-gadolinium-enhanced images on MRI scans [11].
Conclusions
Cardiac calcified amorphous tumor is an extremely rare nonneoplastic cardiac lesion. The pathogenesis of CCAT is unclear. Diagnosing CCAT can be challenging as there is no specific clinical presentation, and it is easy to misdiagnose it as a malignant cardiac tumor. Surgical resection is the only treatment option to reduce symptoms. Excision of the CCAT serves as both definitive diagnosis and the means to prevent embolizations.
Figures
Figure 1.. (A) Transthoracic echocardiography revealed a long strip shape (size, 59×19 mm) extending from the middle of the right ventricular wall. (B) intraoperative findings: appearance of the CCAT. Figure 2.. (A) Microscopic appearance of the excised mass revealed fibrin and extensive calcium deposits (hematoxylin and eosin ×5). (B) Periphery of the lesion showing bluish calcification (hematoxylin and eosin ×10). (C) Preoperative transthoracic echocardiography showed mobile mass (size, 59×19 mm). (D) Postoperative transthoracic echocardiography showed mobile mass (size, 27×11 mm).References:
1.. Reynolds C, Tazelaar HD, Edwards WD, Calcified amorphous tumor of the heart (cardiac CAT): Hum Pathol, 1997; 28; 601-6
2.. de Hemptinne Q, de Cannière D, Vandenbossche JL, Unger P, Cardiac calcified amorphous tumor: A systematic review of the literature: Int J Cardiol Heart Vasc, 2015; 7; 1-5
3.. Kubota H, Fujioka Y, Yoshino H, Cardiac swinging calcified amorphous tumors in end-stage renal failure patients: Ann Thorac Surg, 2010; 90; 1692-94
4.. Yılmaz R, Demir AA, Önür İ, Cardiac calcified amorphous tumors: CT and MRI findings: Diagn Interv Radiol, 2016; 22(6); 519-24
5.. Fussen S, De Boeck BW, Zellweger MJ, Cardiovascular magnetic resonance imaging for diagnosis and clinical management of suspected cardiac masses and tumours: Eur Heart J, 2011; 32(12); 1551-60
6.. Saku K, Tahara N, Takaseya T, Multimodal imaging of cardiac-calcified amorphous tumor: J Nucl Cardiol, 2020; 27(2); 682-85
7.. Griborio-Guzman AG, Aseyev OI, Shah H, Sadreddini M, Cardiac myxomas: Clinical presentation, diagnosis and management: Heart, 2022; 108; 827-33
8.. Samanidis G, Khoury M, Balanika M, Perrea DN, Current challenges in the diagnosis and treatment of cardiac myxoma: Kardiol Pol, 2020; 78; 269-77
9.. Poterucha TJ, Kochav J, O’Connor DS, Rosner GF, Cardiac tumors: Clinical presentation, diagnosis, and management: Curr Treat Options Oncol, 2019; 20; 66
10.. Gabe ED, Rodríguez Correa C, Vigliano C, [Cardiac myxoma. Clinical-pathological correlation.]: Rev Esp Cardiol, 2022; 55; 505-13 [in Spanish]
11.. Ufuk F, Kilic ID, Case 315: Cardiac calcified amorphous tumor: Radiology, 2023; 308; e220881
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