Background: Plasmacytoma, also called plasma cell myeloma or multiple myeloma, is primarily a neoplasm of bone. Extramedullary plasmacytoma is a rare presentation of plasma cell neoplasms, that
occur primarily in the head and neck region. They usually involve the submucoid and lymphoid tissue of the paranasal sinuses or nasopharynx and present as soft tissue masses.Material/Methods: We present a case study of a 65-years old male patient suffering unilateral nasal congestion and exopthalmos due to a solitary extramedullary plasmacytoma of nasal fossa and ethmoid sinuses with orbital extension, treated by surgical excision of the lesion and radiotherapy. Treatment options and the follow-up strategies are discussed, according to the literature data.Conclusions: The possibility of a plasma cell tumour should never be forgotten in the presence of a head and neck neoplasm. Because the neoplasm may signal the presence of multiple myeloma, full evaluation is required to exclude disseminated disease. Surgical excision and / or radiotherapy are suggested for the treatment of extramedullary plasmacytoma.

Keywords: Plasmacytoma, Paranasal Sinuses, Radiotherapy