Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

01 January 2005

Small cell carcinoma of the upper third of the esophagus associated to a squamous carcinoma in situ (collision tumor): immunohistochemical and molecular study

Arianna Coniglio, Guido Tiberio, Monica Busti, Vincenzo Villanacci, Tullio Piardi, Stefano M. Giulini

Case Rep Clin Pract Rev 2005; 6:220-223 :: ID: 428469

Abstract

Background: We report the case of a small cell carcinoma of the upper third of the esophagus associated to a squamous carcinoma in situ (collision tumor). The meaning of collision tumors remains
uncertain. Recently, molecular biology techniques have been used to establish the origin of multiple neoplastic lesions in different organs.
Case Report: The case of a women with a small cell carcinoma of the esophagus associated to a squamous
carcinoma in situ of the overlying epithelium is described. The patient is currently suffering from
multiple bilateral hepatic metastases and pleural lesions. Sections from pre-operative esophageal
biopsies were tested with several antibodies (Chromogranine, Cytokeratin 20, NSE, ACTH, VIP,
Calcitonin, p53) and DNA was extracted for p53 loss of heterozygosity and microsatellite instability
assay. Microscopy observation showed a lesion confined to the submucous layer, associated with
areas of mild-severe dysplasia in the overlying squamous epithelium. Immunohistochemistry showed negativity in both in small cell and squamous cell carcinoma for all markers except chromogranine and p53. Microsatellite stability and LOH in D17S250, D17S513, and D17S830 were observed in both tumors.
Conclusions: In this rare case of collision tumor, the results of immunohistochemistry and molecular analysis were the same in the two tumor components, suggesting that they probably share common
evolutionary pathways based on loss of p53.

Keywords: collision tumor, esophageal carcinoma, p53, Loss of Heterozygosity

Add Comment 0 Comments

37

In Press

12 Feb 2024 : Case report  USA

Erdheim-Chester Disease Occult on Radiographs and CT but Visible on MRI and PET

Am J Case Rep In Press; DOI: 10.12659/AJCR.941169  

0:00

12 Feb 2024 : Case report  USA

Surgical Treatment of Spontaneous Superficial Temporal Artery Arteriovenous Malformation: A Case Report

Am J Case Rep In Press; DOI: 10.12659/AJCR.942839  

13 Feb 2024 : Case report  Bahrain

Warfarin Woes: A Rare Case of Hemoperitoneum with Intramural Small Bowel Hematoma

Am J Case Rep In Press; DOI: 10.12659/AJCR.943519  

13 Feb 2024 : Case report  Portugal

Hemorrhagic Presentation in Primary Central Nervous System Lymphoma: A Case Study

Am J Case Rep In Press; DOI: 10.12659/AJCR.942951  

Most Viewed Current Articles

07 Mar 2024 : Case report  USA

Neurocysticercosis Presenting as Migraine in the United States

DOI :10.12659/AJCR.943133

Am J Case Rep 2024; 25:e943133

0:00

10 Jan 2022 : Case report  Germany

A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...

DOI :10.12659/AJCR.935263

Am J Case Rep 2022; 23:e935263

19 Jul 2022 : Case report  Saudi Arabia

Atlantoaxial Subluxation Secondary to SARS-CoV-2 Infection: A Rare Orthopedic Complication from COVID-19

DOI :10.12659/AJCR.936128

Am J Case Rep 2022; 23:e936128

23 Feb 2022 : Case report  USA

Penile Necrosis Associated with Local Intravenous Injection of Cocaine

DOI :10.12659/AJCR.935250

Am J Case Rep 2022; 23:e935250

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923