01 January 2005
Small cell carcinoma of the upper third of the esophagus associated to a squamous carcinoma in situ (collision tumor): immunohistochemical and molecular study
Arianna Coniglio, Guido Tiberio, Monica Busti, Vincenzo Villanacci, Tullio Piardi, Stefano M. GiuliniCase Rep Clin Pract Rev 2005; 6:220-223 :: ID: 428469
Abstract
Background: We report the case of a small cell carcinoma of the upper third of the esophagus associated to a squamous carcinoma in situ (collision tumor). The meaning of collision tumors remains
uncertain. Recently, molecular biology techniques have been used to establish the origin of multiple neoplastic lesions in different organs.
Case Report: The case of a women with a small cell carcinoma of the esophagus associated to a squamous
carcinoma in situ of the overlying epithelium is described. The patient is currently suffering from
multiple bilateral hepatic metastases and pleural lesions. Sections from pre-operative esophageal
biopsies were tested with several antibodies (Chromogranine, Cytokeratin 20, NSE, ACTH, VIP,
Calcitonin, p53) and DNA was extracted for p53 loss of heterozygosity and microsatellite instability
assay. Microscopy observation showed a lesion confined to the submucous layer, associated with
areas of mild-severe dysplasia in the overlying squamous epithelium. Immunohistochemistry showed negativity in both in small cell and squamous cell carcinoma for all markers except chromogranine and p53. Microsatellite stability and LOH in D17S250, D17S513, and D17S830 were observed in both tumors.
Conclusions: In this rare case of collision tumor, the results of immunohistochemistry and molecular analysis were the same in the two tumor components, suggesting that they probably share common
evolutionary pathways based on loss of p53.
Keywords: collision tumor, esophageal carcinoma, p53, Loss of Heterozygosity
37
In Press
12 Feb 2024 : Case report
Erdheim-Chester Disease Occult on Radiographs and CT but Visible on MRI and PETAm J Case Rep In Press; DOI: 10.12659/AJCR.941169
12 Feb 2024 : Case report
Surgical Treatment of Spontaneous Superficial Temporal Artery Arteriovenous Malformation: A Case ReportAm J Case Rep In Press; DOI: 10.12659/AJCR.942839
13 Feb 2024 : Case report
Warfarin Woes: A Rare Case of Hemoperitoneum with Intramural Small Bowel HematomaAm J Case Rep In Press; DOI: 10.12659/AJCR.943519
13 Feb 2024 : Case report
Hemorrhagic Presentation in Primary Central Nervous System Lymphoma: A Case StudyAm J Case Rep In Press; DOI: 10.12659/AJCR.942951
Most Viewed Current Articles
07 Mar 2024 : Case report
Neurocysticercosis Presenting as Migraine in the United StatesDOI :10.12659/AJCR.943133
Am J Case Rep 2024; 25:e943133
10 Jan 2022 : Case report
A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...DOI :10.12659/AJCR.935263
Am J Case Rep 2022; 23:e935263
19 Jul 2022 : Case report
Atlantoaxial Subluxation Secondary to SARS-CoV-2 Infection: A Rare Orthopedic Complication from COVID-19DOI :10.12659/AJCR.936128
Am J Case Rep 2022; 23:e936128
23 Feb 2022 : Case report
Penile Necrosis Associated with Local Intravenous Injection of CocaineDOI :10.12659/AJCR.935250
Am J Case Rep 2022; 23:e935250