01 January 2005
Minocycline-induced hepatitis with autoimmune features
Shusuke Morizono, Munechika Enjoji, Shinichiro Takao, Eiichiro Arimura, Motoyuki Kohjima, Yuzuru Miyagi, Tsuyosi Yoshimoto, Kazuhiro Kotoh, Makoto NakamutaCase Rep Clin Pract Rev 2005; 6:144-147 :: ID: 428842
Abstract
Background: Prolonged treatment with minocycline for acne vulgaris has been reported to induce the development of autoimmune phenomena.Case Report: An adolescent male presented with active hepatitis after taking long term minocycline for acne vulgaris. The patient was jaundiced and experienced profound malaise. He had severe hepatitis with an alanine aminotransferase concentration of 876 IU/L, a total bilirubin concentration of 27.8 mg/dL, a prolonged prothrombin time of 20%, and a strongly positive antinuclear antibody titer. Hepatitis viral screens and other autoantibody tests gave negative results. Liver biopsy showed moderately severe chronic active hepatitis. Although liver transplantation was considered, the patient symptoms resolved upon treatment with corticosteroids in addition to discontinuation of minocycline, and remission was achieved. The patient has had no recurrence of symptoms or biochemical abnormalities after the withdrawal of corticosteroids, emphasizing that these reactions were likely due to minocycline-related autoimmune hepatitis.Conclusions: Liver function should be carefully monitored in patients who receive prolonged minocycline therapy, and minocycline-induced hepatitis should be recognized at an early stage. Because this form of hepatitis tends to resolve slowly following cessation of minocycline, treatment with corticosteroids should also be considered to fasten recovery.
Keywords: Minocycline, autoimmune hepatitis, corticosteroid
20
In Press
12 Feb 2024 : Case report
Erdheim-Chester Disease Occult on Radiographs and CT but Visible on MRI and PETAm J Case Rep In Press; DOI: 10.12659/AJCR.941169
12 Feb 2024 : Case report
Surgical Treatment of Spontaneous Superficial Temporal Artery Arteriovenous Malformation: A Case ReportAm J Case Rep In Press; DOI: 10.12659/AJCR.942839
13 Feb 2024 : Case report
Warfarin Woes: A Rare Case of Hemoperitoneum with Intramural Small Bowel HematomaAm J Case Rep In Press; DOI: 10.12659/AJCR.943519
13 Feb 2024 : Case report
Hemorrhagic Presentation in Primary Central Nervous System Lymphoma: A Case StudyAm J Case Rep In Press; DOI: 10.12659/AJCR.942951
Most Viewed Current Articles
07 Mar 2024 : Case report
Neurocysticercosis Presenting as Migraine in the United StatesDOI :10.12659/AJCR.943133
Am J Case Rep 2024; 25:e943133
10 Jan 2022 : Case report
A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...DOI :10.12659/AJCR.935263
Am J Case Rep 2022; 23:e935263
19 Jul 2022 : Case report
Atlantoaxial Subluxation Secondary to SARS-CoV-2 Infection: A Rare Orthopedic Complication from COVID-19DOI :10.12659/AJCR.936128
Am J Case Rep 2022; 23:e936128
23 Feb 2022 : Case report
Penile Necrosis Associated with Local Intravenous Injection of CocaineDOI :10.12659/AJCR.935250
Am J Case Rep 2022; 23:e935250