Background: Castleman’s disease (giant lymph node hyperplasia) is an extremely rare lymphoproliferative disease, the etiology and pathogenesis of which are unknown. It generally involves the mediastinum and abdomen, rarely affecting other regions.Case Report: A 31-year-old male sought treatment for a mass in the inguinal region. Laboratory examinations showed leukocytosis, increased ESR and CRP, and a mass in the medial proximal thigh was identified on MRI. Excisional biopsy was performed, and histopathological examination led to a diagnosis of hyaline-vascular type Castleman’s disease. The patient received neither chemotherapy nor radiotherapy, and there was no recurrence during 4-year follow-up. Conclusions: In this report, a case of hyaline-vascular type Castleman’s disease with inguinal localization, not described previously, is presented.

Keywords: Castleman’s disease