Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

01 February 2006

Hepatotoxicity of chloroquine treatment in patient with porphyria cutanea tarda

Piotr Stalke , Katarzyna Sikorska , Zofia Michalska , Julian Stolarczyk , Hanna Trocha

Case Rep Clin Pract Rev 2006; 7:18-22 :: ID: 445545

Abstract

Background: Porphyria cutanea tarda (PCT) is a disorder of porphyrin metabolism associated with decreased activity of uroporphyrinogen decarboxylase (URO-D) activity in liver. There are two main
options of PCT therapy: phlebotomy and chloroquine administration, however, some side effects were described in both.
Case Report: A 50-year-old Caucasian man was admitted to hospital because of symptoms of severe liver
damage, fever up to 39,5ºC with chills, and vesicular eruptions. A month before the patient had developed erythema on the face and hands that left flat erosions. PCT was diagnosed and the patient was treated with chloroquine 500 mg/daily, prednisone 5 mg/daily, and ornithine 450 mg/daily. After a week of treatment, he had developed headaches, nausea, vomiting, fever and subicterus. On admission to hospital hypertrichosis involving the face, dry and reddened skin on the sun-exposed-areas with many crusts and ruptured bullas – some of which had eroded, and enlarged liver were found. The patient’s urine was dark red. Laboratory tests suggested severe
liver damage with haemostatic disorders and hyperleucocytosis. Urine level of porphyrins was
elevated. Histological study of the skin biopsy material revealed deposits of immunoglobulins.
Liver biopsy showed macrovesicular steatosis and iron deposits in hepatocytes. Septicaemia, viral and autoimmune hepatitis were excluded. In view of the clinical aspects the diagnosis of toxic liver damage after chloroquine treatment during the course of PTC was made. The patient was treated with glucose infusion, prednisone, fresh frozen plasma and he resolved.
Conclusions: The symptoms of severe liver damage similar to the acute viral hepatitis could be observed after chloroquine treatment in patient with PCT.

Keywords: Porphyria Cutanea Tarda, Chloroquine, Hemosiderosis, Hepatitis, toxic

Add Comment 0 Comments

322

In Press

Case report  Italy

Twenty Years of Continuous Bisphosphonate Use Leading to Atypical Bilateral Femoral Fractures: A Case Report

Am J Case Rep In Press; DOI: 10.12659/AJCR.946435  

Case report  USA

Impact of Hypoglossal Nerve Stimulation on Nocturnal Asystole in a Patient with Severe Obstructive Sleep Ap...

Am J Case Rep In Press; DOI: 10.12659/AJCR.947160  

Case report  Indonesia

Fatal Progression of Vulvar Cancer in Pregnancy: A Case Report on Delayed Intervention

Am J Case Rep In Press; DOI: 10.12659/AJCR.947567  

Case report  Saudi Arabia

Surgical Outcomes of Right Traumatic Diaphragmatic Rupture with Grade 3 Liver Injury: A Report of 2 Cases

Am J Case Rep In Press; DOI: 10.12659/AJCR.948238  

Most Viewed Current Articles

21 Jun 2024 : Case report  China (mainland) 100,395

Intracranial Parasitic Fetus in a Living Infant: A Case Study with Surgical Intervention and Prognosis Anal...

DOI :10.12659/AJCR.944371

Am J Case Rep 2024; 25:e944371

0:00

07 Mar 2024 : Case report  USA 53,743

Neurocysticercosis Presenting as Migraine in the United States

DOI :10.12659/AJCR.943133

Am J Case Rep 2024; 25:e943133

0:00

20 Nov 2023 : Case report  Saudi Arabia 36,265

Azithromycin Treatment for Acne Vulgaris: A Case Report on the Risk of Clostridioides difficile Infection

DOI :10.12659/AJCR.941424

Am J Case Rep 2023; 24:e941424

0:00

07 Jul 2023 : Case report  Saudi Arabia 24,994

A Classical Case of Cesarean Scar Endometriosis in a 35-Year-Old Woman Presenting with Cyclical Abdominal P...

DOI :10.12659/AJCR.940200

Am J Case Rep 2023; 24:e940200

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923