Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

01 February 2006

Formation of rheumatoid pulmonary nodules during the leflunomide treatment

Štefan Alušík, Jan Fanta, Václav Eis, Václav Mandys, Jan Pavlíček

Case Rep Clin Pract Rev 2006; 7:139-142 :: ID: 452142

Abstract

Background: Rheumatoid nodules develop mostly subcutaneously, they are less common in other organs.
Recent studies have described formation of rheumatoid nodules or growth acceleration of existing nodules in relation to the treatment. The development or growth acceleration of rheumatoid nodules is known to be related to the treatment with methotrexate, etanercept, infliximab and leflunomide.
Case Report: A 59-year-old female patient was treated 9 years for seropositive rheumatoid arthritis. She
took hydroxychloroquine, sulfasalazine, methotrexate and etanercept successively. Until then, the patient had suffered no rheumatoid nodules (not even subcutaneous). Isolated rheumatoid nodules were formed in her lungs when treated with leflunomide. The patient has been monitored after discontinuation of leflunomide treatment for the period of 20 months and only a mild progression of her lung disease has occurred.
Conclusions: Isolated rheumatoid nodules were formed in the lungs of our patient during leflunomide
treatment. In addition to methotrexate, etanercept and infliximab, leflunomide can probably also cause the formation and growth acceleration of rheumatoid nodules.

Keywords: rheumatoid arthritis, rheumatoid nodules, lungs, leflunomide

Add Comment 0 Comments

112

In Press

Case report  Portugal

Bartter Syndrome Presenting as Arginine-Vasopressin Resistance: A Report of 2 Cases

Am J Case Rep In Press; DOI: 10.12659/AJCR.942872  

Case report  China (mainland)

Extended Left Hemihapatectomy with Right Hepatic Artery Reconstruction for Primary Hepatic Neuroendocrine N...

Am J Case Rep In Press; DOI: 10.12659/AJCR.943721  

Case report  Austria

Smoking-Associated Endotracheal Hair Growth: A Case Report on Tracheal Complications

Am J Case Rep In Press; DOI: 10.12659/AJCR.943909  

Case report  Japan

Virtual Reality-Guided Simulation for Percutaneous Coronary Intervention in a Patient with Anatomical Anoma...

Am J Case Rep In Press; DOI: 10.12659/AJCR.944485  

Most Viewed Current Articles

07 Mar 2024 : Case report  USA 38,124

Neurocysticercosis Presenting as Migraine in the United States

DOI :10.12659/AJCR.943133

Am J Case Rep 2024; 25:e943133

0:00

10 Jan 2022 : Case report  Germany 31,073

A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...

DOI :10.12659/AJCR.935263

Am J Case Rep 2022; 23:e935263

19 Jul 2022 : Case report  Saudi Arabia 17,693

Atlantoaxial Subluxation Secondary to SARS-CoV-2 Infection: A Rare Orthopedic Complication from COVID-19

DOI :10.12659/AJCR.936128

Am J Case Rep 2022; 23:e936128

23 Feb 2022 : Case report  USA 17,607

Penile Necrosis Associated with Local Intravenous Injection of Cocaine

DOI :10.12659/AJCR.935250

Am J Case Rep 2022; 23:e935250

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923