Background: Although regular insulin and neutral protamine Hagedorn (NPH) are used classically in pregnant diabetics, the use of insulin anologues during pregnancy has become a current issue.
Case Report: Our case is a 33 year-old female with type 1 diabetes mellitus (DM) receiving intensive treatment of both long acting and short acting insulin anologues at 28th week of her pregnancy. She was hospitalized in obstetrics ward due to decreased amount of placental blood flow and gave birth to a 1100 g weight, 35 cm height baby. The neonate did not have any congenital
malformations. However the neonate had respiratory failure for the first 2 days. The baby has been followed for 8 months, now without any health problem. She is 7245 g of weight, 62 cm of hight and the circumference of her head is 43.5 cm. She has normal mental development.
Conclusions: The safety of using insulin analogues of both short acting and long acting types in pregnant patients with DM have not been proven precisely. However due to the data in the literature, they can be used in pregnant women with taking informed consent.

Keywords: Pregnancy, insulin analogues