Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

01 February 2006

Anastomosis wrapping with gentamicin-containing collagen sponge in rectal cancer patients following sphincter-preserving total mesorectal excision without defunctioning stoma

Bartłomiej Szynglarewicz, Rafał Matkowski, Józef Forgacz, Marek Pudełko, Zygmunt Grzebieniak

Case Rep Clin Pract Rev 2006; 7:267-271 :: ID: 467991


Background: Since the introduction of total mesorectal excision (TME) better regional control resulting in low recurrence rate and improved survival can be achieved for rectal cancer patients. In spite of the oncological advantages sphincter-preserving TME is related to the risk of anastomotic dehiscence and septic complications increasing postoperative morbidity and mortality.
Case Report: Consecutive ten patients in 33-84 years of age (mean 59.9, median 57.5) with histologically confirmed rectal cancer were studied prospectively. Patients underwent curative R0 anterior resection. Operations were performed strictly according to the TME method. Straight endto-
end anastomoses were constructed with double-stapling technique. Site of the anastomosis ranged 5-8 cm (mean 6.7, median 6.5) from the anal verge. In all cases gentamicin-containing collagen sponge was applied into pelvis cavity at the presacral area and wrapped around the anastomosis. For all patients defunctioning stoma was avoided. There was no postoperative
mortality. Neither clinical symptoms of anastomotic leakage nor any other septic complications in postoperative period were observed. Sponge was well tolerated and no adverse effects were noticed.
Conclusions: Application of gentamicin-containing collagen sponge at the site of the anastomosis after anterior resection with TME may be related with decreased rate of early septic postoperative complications including anastomotic leak despite the lack of defunctioning stoma. Further
controlled randomized studies should be performed to prove its clinical value for routine surgical practice. Cost-effectiveness analyses are also needed.

Keywords: rectal cancer, Anterior resection, total mesorectal excision, anastomotic leakage, collagen sponge, gentamicin


In Press

27 Jan 2023 : Case report  Spain

A 37-Year-Old Man with Familial Hereditary Hemorrhagic Telangiectasia and Pulmonary Arteriovenous Malformat...

Am J Case Rep In Press; DOI: 10.12659/AJCR.938548  

26 Jan 2023 : Case report  Spain

A 39-Year-Old Woman with Endometriosis Who Developed a Subcapsular Liver Hematoma Following Laparotomic Sur...

Am J Case Rep In Press; DOI: 10.12659/AJCR.938169  

26 Jan 2023 : Case report  USA

Optic Neuritis as a Consequence of Long-Term Medical Treatment Using Anastrozole: A Case Report

Am J Case Rep In Press; DOI: 10.12659/AJCR.939026  

26 Jan 2023 : Case report  USA

A Rare Case of Ruptured Appendicitis Secondary to Metastatic Ovarian Cancer

Am J Case Rep In Press; DOI: 10.12659/AJCR.938982  

Most Viewed Current Articles

13 Jul 2022 : Case report  USA

Whistling Scrotum: An Unusual Presentation of Pneumomediastinum in the Setting of an Open Scrotal Wound

DOI :10.12659/AJCR.936441

Am J Case Rep 2022; 23:e936441

06 Dec 2021 : Case report  Brazil

Lipedema Can Be Treated Non-Surgically: A Report of 5 Cases

DOI :10.12659/AJCR.934406

Am J Case Rep 2021; 22:e934406

23 Feb 2022 : Case report  USA

Penile Necrosis Associated with Local Intravenous Injection of Cocaine

DOI :10.12659/AJCR.935250

Am J Case Rep 2022; 23:e935250

17 Feb 2022 : Case report  Oman

Myocarditis, Pulmonary Hemorrhage, and Extensive Myositis with Rhabdomyolysis 12 Days After First Dose of P...

DOI :10.12659/AJCR.934399

Am J Case Rep 2022; 23:e934399

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923