Background: Serous cystic pancreatic tumours are unique among all pancreatic cystic neoplasms in that they are almost always benign and the diagnostic challenge for the surgical pathologist is to recognise the spectrum of architectural variations that may lead to misdiagnosis either pre or postoperatively. They are more frequently identified as the imaging techniques improve in time.
Case Report: We present two cases of pancreatic serous microcystic adenoma bot of which were diagnosed incidentally during clinical and radiologic evaluations for unrelated reasons.The first patient referred to the clinic with epigastric pain and nausea. During clinical evaluation a cystic mass in distal pancreas was noted. Second patient had two cystic lesions in liver and one cystic lesion in the pancreatic head which were considered as consistent with hydatid cysts by radiologists. Distal and proximal pancreatectomies were performed for the first and second patient respectively. Histopathologic diagnosis of the specimens was serous microcystic adenoma of pancreas.
Conclusions: Despite their rarity, serous cystadenomas should be kept in mind by pathologists and radiologists in the differential diagnosis of the cystic neoplasms of pancreas.

Keywords: Pancreas, serous microcystic adenoma, Surgery