19 February 2008
Successful management of acute renal failure after high-dose methotrexate in a patient with relapsed osteosarcoma
Lauro José Gregianin, Cláudio Galvão de Castro Junior, Renato Eick, Algemir Lunardi BrunettoAm J Case Rep 2008; 9:93-96 :: ID: 828543
Abstract
Background: The incidence of reported acute renal failure (ARF) due to methotrexate is about 1.8%. Although standard of care of this condition includes hyperhidration and leucovorin rescue, hemodialysis may be considered in some cases.
Case Report: We present the case of a 13-year-old girl with a relapsed osteosarcoma three months after the end of first treatment. Three pulmonary nodes were removed and after she received intravenous methotrexate (12 g/m²) she developed a severe ARF, seizures and pancytopenia. The patient underwent to hemodialysis and folinic acid rescue. She recovered and is in complete remission with normal renal function 60 months after the end of the treatment.
Conclusions: Although the indication of hemodialysis is not a consensus, we suggest this procedure should be indicated to treat severe ARF due to methotrexate when Carboxypeptidase G2 is not readily available.
Keywords: Acute renal failure (ARF), adverse effects, Methotrexate, hemodialysis
SARS-CoV-2/COVID-19
29 June 2022 : Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.936896
16 June 2022 : Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.936498
13 June 2022 : Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.936889
13 June 2022 : Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.936128
In Press
01 Jul 2022 : Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.936536
30 Jun 2022 : Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.937061
30 Jun 2022 : Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.936896
30 Jun 2022 : Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.936967
Most Viewed Current Articles
23 Feb 2022 : Case report
DOI :10.12659/AJCR.935250
Am J Case Rep 2022; 23:e935250
17 Feb 2022 : Case report
DOI :10.12659/AJCR.934399
Am J Case Rep 2022; 23:e934399
06 Dec 2021 : Case report
DOI :10.12659/AJCR.934406
Am J Case Rep 2021; 22:e934406
09 Feb 2022 : Case report
DOI :10.12659/AJCR.934744
Am J Case Rep 2022; 23:e934744