Background: Jejunojejunal intussusception in adult is a rare condition. Jejunal lipoma induced intussusception in adult cases in literature are limited in number.
Case Report: The present report describes a case of proximal jejunojejunal intussusception secondary to submucosal lipoma in a adult with history of severe nausea and vomiting. The diagnosis was suspected in computed tomography preoperatively. An intraluminal mass with a diameter of 2.5 cm was palpated at laparatomy after reduction of intussusception. Partial resection and jejunojejunostomy was performed. Pathological evaluation revealed jejunal submucosal lipoma.
Conclusions: In conclusion intussusception and/or masses located in proximal part of small intestine must be kept in mind in cases with severe nausea and vomiting without a known origin and resulting in renal failure.

Keywords: Intussusception, Jejunum, Lipoma