Background: Pancreatic encephalopathy is a rare complication of acute pancreatitis. Acute pancreatitis is associated with a variety of complications that can involve the CNS, with altered mental status (AMS), Pulmonary, Cardiac, Renal, Hematology, Gastrointestinal systems with various clinical manifestations. Pancreatic encephalopathy (PE) could be a contributing factor to the persistence of altered mental status in patients presenting with AMS and acute pancreatitis with persistence of AMS even after the resolution of metabolic changes in this patient.
Case Report: We describe a case of altered mental status in a patient with acute pancreatitis and diabetic ketoacidosis, presenting with persistent neurological symptoms which Persisted even after complete resolution of metabolic changes.
Conclusions: Pancreatic encephalopathy is a main contributor to persistent neurological changes in patients with acute pancreatitis. It is frequently under-diagnosed. Look for other causes of AMS in patients with acute pancreatitis presenting with AMS that does not resolve with the resolution of metabolic changes .

Keywords: myelin basic protein, Phospholipase A2, PANCREATIC ENCEPHALOPATHY, AMS and pancreatitis