Background: Kaposi’s sarcoma (KS) is a uni- or multifocal neoplasm arising from transformed endothelial cells of both lymphatic and vascular origin. The most common sites of extra-mucocutaneous KS associated with human immunodefi ciency virus (HIV) infection are the lymph nodes followed by the gastro-intestinal tract and the lungs. KS confined to the penis is extremely rare.
Case Report: We present a 55-year-old man who presented with a painless mass 1.5 cm in diameter on the the glans penis for three months. Histopathological examination showed proliferative vascular structures and spindle cells forming slits, with immunoreactivity to CD-34 in vascular spaces in the dermis.at serologically the patient was HIV-negative.
Conclusions: Isolated penile KS is extremely rare in HIV-negative men, but should be considered in the differential diagnosis of atypical penile lesions.

Keywords: Kaposi sarcoma, Penis, HIV-negative