Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

25 September 2009

Clinical effectiveness of ezetimibe for a non-obese patient with nonalcoholic fatty liver disease

Munechika Enjoji, Masatake Tanaka, Masayuki Miyazaki, Nobito Higuchi, Masaki Kato, Kazuhiro Kotoh, Kazuhisa Matsunaga, Takuya Nishinakagawa, Kazuyuki Machida, Manabu Nakashima, Makoto Nakamuta

Am J Case Rep 2009; 10:145-148 :: ID: 878193

Abstract

Background: We recently examined the distribution of abdominal fat, dietary intake and biochemical data in patients with nonalcoholic fatty liver disease (NAFLD) and compared these factors between nonobese and obese individuals. We found that non-obese NAFLD patients did not necessarily exhibit insulin resistance and/or dysregulated secretion of adipocytokines. However, the dietary cholesterol intake was superabundant and the dietary intake of polyunsaturated fatty acids was significantly lower in non-obese patients compared with obese patients, although total energy and carbohydrate intake was not excessive. Therefore, surplus cholesterol intake appears to be a factor associated with NAFLD development and liver injury.
Case Report: In a non-obese 48-year-old male patient with NAFLD, in whom ursodeoxycholic acid and tocopherol acetate treatments were not effective, we tested a novel approach using the cholesterol absorption inhibitor ezetimibe. Without any dietary or exercise modifi cation, 10 mg/day of ezetimibe was started instead of tocopherol acetate. Although body weight and body mass index remained nearly constant, the serum levels of transaminases promptly decreased into the normal range, which was accompanied by a decrease in serum total cholesterol and LDL-cholesterol exceeding 10%.
Conclusions: Ezetimibe may offer a novel treatment for NAFLD, particularly in non-obese patients.

Keywords: ezetimibe, Nonalcoholic fatty liver disease, Cholesterol

Add Comment 0 Comments

In Press

01 Mar 2024 : Case report  USA

Complicated Treatment Course of Severe Asymptomatic Hypertriglyceridemia: A Case Report and Literature Review

Am J Case Rep In Press; DOI: 10.12659/AJCR.943858  

04 Mar 2024 : Case report  Switzerland

Unintentional Plastic Blister Ingestion Leading to Intestinal Perforation: A Report of Two Cases

Am J Case Rep In Press; DOI: 10.12659/AJCR.943514  

04 Mar 2024 : Case report  Belgium

Nivolumab-Induced Cytokine Release Syndrome: A Case Report and Literature Review

Am J Case Rep In Press; DOI: 10.12659/AJCR.941835  

05 Mar 2024 : Case report  USA

Intrapulmonary Shunting and Paradoxical Air Embolism in Liver Transplantation: A Case Report

Am J Case Rep In Press; DOI: 10.12659/AJCR.943042  

Most Viewed Current Articles

07 Mar 2024 : Case report  USA

Neurocysticercosis Presenting as Migraine in the United States

DOI :10.12659/AJCR.943133

Am J Case Rep 2024; 25:e943133

0:00

10 Jan 2022 : Case report  Germany

A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...

DOI :10.12659/AJCR.935263

Am J Case Rep 2022; 23:e935263

19 Jul 2022 : Case report  Saudi Arabia

Atlantoaxial Subluxation Secondary to SARS-CoV-2 Infection: A Rare Orthopedic Complication from COVID-19

DOI :10.12659/AJCR.936128

Am J Case Rep 2022; 23:e936128

23 Feb 2022 : Case report  USA

Penile Necrosis Associated with Local Intravenous Injection of Cocaine

DOI :10.12659/AJCR.935250

Am J Case Rep 2022; 23:e935250

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923