Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

29 April 2010

A rare case of recurrent anaphylaxis mimicking stenocardia due to hypersensitivity to omeprazole

Marita Nittner-Marszalska, Agnieszka Muszynska, Andrzej M. Fal, Maryla Krasnowska, Bernard Panaszek

Am J Case Rep 2010; 11:78-82 :: ID: 878550

Abstract

Background: Anaphylaxis is the most serious and potentially life-threatening reaction which can occur after any drug. Although its clinical picture is well defined, its individual manifestations may vary greatly in their onset, time-course, and clinical symptoms, which makes the its diagnosis difficult.
Case Report: A case of recurrent IgE-dependent anaphylaxis is reported which was induced by omeprazole with cross-sensitivity to other PPIs in a 67-year-old woman with coronary heart disease in whom the recurrent anaphylactic symptoms were mistaken for episodes of stenocardial pain. The IgE-dependent mechanism of this reaction and the cross-reactivity with pantoprazole were documented by positive intradermal tests with this drugs. Oral challenge with an H2 blocker, dictated by the postulated cross-reactivity of PPIs and all imidazoles, was performed. The result of an oral challenge with ranitidine was negative.
Conclusions: Proton pump inhibitors, commonly regarded as safe, can cause severe anaphylaxis. The diagnosis of anaphylaxis in elderly patients is difficult because anaphylactic symptoms may imitate those of many coexisting disorders. Symptoms of drug-induced anaphylaxis can recur in reactions to the same factor, presenting a varied clinical picture and progressive intensity.

Keywords: omeprazole, Anaphylaxis, proton pump inhibitors

Add Comment 0 Comments

539 3

In Press

08 Jun 2023 : Case report  Latvia

Chylothorax: A Tangled Road to Definitive Diagnosis of Non-Hodgkin Lymphoma

Am J Case Rep In Press; DOI: 10.12659/AJCR.939098  

06 Jun 2023 : Case report  Saudi Arabia

A Classical Case of Cesarean Scar Endometriosis in a 35-Year-Old Woman Presenting with Cyclical Abdominal P...

Am J Case Rep In Press; DOI: 10.12659/AJCR.940200  

05 Jun 2023 : Case report  USA

Peri-Hilar Cystic Lymphangioma Mimicking a Biliary Cystic Lesion Causing Biliary Obstruction: A Case Report...

Am J Case Rep In Press; DOI: 10.12659/AJCR.939421  

05 Jun 2023 : Case report  Palestinian Territory, Occupied

Recurrent Bioprosthetic Valve Serratia marcescens Endocarditis in Intravenous Drug Users

Am J Case Rep In Press; DOI: 10.12659/AJCR.939292  

Most Viewed Current Articles

06 Dec 2021 : Case report  Brazil

Lipedema Can Be Treated Non-Surgically: A Report of 5 Cases

DOI :10.12659/AJCR.934406

Am J Case Rep 2021; 22:e934406

13 Jul 2022 : Case report  USA

Whistling Scrotum: An Unusual Presentation of Pneumomediastinum in the Setting of an Open Scrotal Wound

DOI :10.12659/AJCR.936441

Am J Case Rep 2022; 23:e936441

07 Dec 2021 : Case report  USA

Edwardsiella tarda: A Classic Presentation of a Rare Fatal Infection, with Possible New Background Risk Fac...

DOI :10.12659/AJCR.934347

Am J Case Rep 2021; 22:e934347

23 Feb 2022 : Case report  USA

Penile Necrosis Associated with Local Intravenous Injection of Cocaine

DOI :10.12659/AJCR.935250

Am J Case Rep 2022; 23:e935250

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923