Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

10 May 2010

Dialyzable leukocyte extracts (transfer factor) as adjuvant therapy for fungal keratitis

Concepcion Santacruz-Valdes, Gustavo Aguilar, Sergio Estrada-Parra, Mayra Perez-Tapia, Maria C Jimenez-Martinez

Am J Case Rep 2010; 11: :: ID: 878562


Background: Fungal keratitis is a rare disorder that affects the cornea. Management is difficult and the prognosis is poor. Patients may develop severe complications that include loss of vision due to mycotic extension into the anterior chamber. Transfer Factors (TF) are dialyzable leukocyte extracts that have been widely used as adjuvant for treating patients with infectious diseases and/or with deficient cell-mediated response.
Case Report: We present here the visual and immunological findings of a 33-year-old man with fungal keratitis treated with conventional therapy plus dialyzable leukocyte extracts. After TF therapy, we observed diminished infiltration of the corneal stroma and epithelial healing, interestingly the systemic immunological changes characterized by increased frequency of IFN-g+ cells, were coincident with the clinical progress observed in the patient.
Conclusions: To the authors’ knowledge, this is the first report of a case in which TF were used to improve treatment of a patient with an ocular fungal infection. TF therapy could act as a systemic immunological booster, inducing a Th1 response, characterized by an increase of IFN-g+ T cells that could influence the ocular microenvironment.

Keywords: dialyzable leukocyte extracts, immune response, fungal keratitis, Transfer Factor

Add Comment 0 Comments

In Press

Case report  China (mainland)

Intracranial Parasitic Fetus in a Living Infant: A Case Study with Surgical Intervention and Prognosis Anal...

Am J Case Rep In Press; DOI: 10.12659/AJCR.944371  

Case report  Jordan

Blue Toe Syndrome in Behçet’s Disease: A Case Report

Am J Case Rep In Press; DOI: 10.12659/AJCR.943813  

Case report  South Korea

A Rare Case of Stroke in a 76-Year-Old Woman: Left Atrial Papillary Fibroelastoma as the Culprit

Am J Case Rep In Press; DOI: 10.12659/AJCR.943568  

Case report  Kosovo

A 74-Year-Old Man with Severe Comorbidities and Successful Abdominal Aortic Aneurysm Repair with Thoracic S...

Am J Case Rep In Press; DOI: 10.12659/AJCR.943702  

Most Viewed Current Articles

07 Mar 2024 : Case report  USA 38,296

Neurocysticercosis Presenting as Migraine in the United States

DOI :10.12659/AJCR.943133

Am J Case Rep 2024; 25:e943133


10 Jan 2022 : Case report  Germany 31,112

A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...

DOI :10.12659/AJCR.935263

Am J Case Rep 2022; 23:e935263

19 Jul 2022 : Case report  Saudi Arabia 17,714

Atlantoaxial Subluxation Secondary to SARS-CoV-2 Infection: A Rare Orthopedic Complication from COVID-19

DOI :10.12659/AJCR.936128

Am J Case Rep 2022; 23:e936128

23 Feb 2022 : Case report  USA 17,684

Penile Necrosis Associated with Local Intravenous Injection of Cocaine

DOI :10.12659/AJCR.935250

Am J Case Rep 2022; 23:e935250

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923