05 July 2010
Am J Case Rep 2010; 11:134-137 :: ID: 881002
Background: The presence of melanin-containing cells is an occasional finding in the female genital tract. The origin and clinical significance of these cells are debatable and still unknown. These lesions are described under various designations from benign to malign, such as melanosis, stromal melanocytosis or blue nevus and malign melanoma either primary or metastatic. The occurrence of melanin-containing cells in the endometrial stroma, which is designated as a blue nevus of the endometrium, has been documented only twice previously. However, searching the literature for melanosis of the endometrium, namely melanin detection in both stromal and epithelial cells, not a single report was found.
Case Report: A 45-year-old woman, having oligomenorrhea for the past 2 years, and who eventually had profuse bleeding, underwent endometrial curettage. Our case was an incidental finding of small aggregates of short spindle cells with finely granular, dark brown pigment in the curettage specimen. The histochemical characteristic of the pigment was melanin, and was also noted both within the glandular epithelial and the stromal cells.
Conclusions: As a consequence, our lesion from the endometrium might be the first documented example of extracutaneous endometrial melanosis.
Keywords: Endometrium, Melanosis, melanin, stroma, glandular epithelium
18 Jan 2024 : Case reportA Case of Left-Sided Acute Appendicitis in a 45-Year-Old Man with Situs Inversus Totalis Managed by Emergen...
Am J Case Rep In Press; DOI: 10.12659/AJCR.942323
23 Jan 2024 : Case reportCloacal Dysgenesis Sequence in a Preterm Neonate
Am J Case Rep In Press; DOI: 10.12659/AJCR.942203
09 Feb 2024 : Case reportA Case of Trauma-Related Angioedema of the Airway in a Patient on an Angiotensin Receptor Blocker
Am J Case Rep In Press; DOI: 10.12659/AJCR.943407
Most Viewed Current Articles
10 Jan 2022 : Case reportA Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...
Am J Case Rep 2022; 23:e935263
19 Jul 2022 : Case reportAtlantoaxial Subluxation Secondary to SARS-CoV-2 Infection: A Rare Orthopedic Complication from COVID-19
Am J Case Rep 2022; 23:e936128
05 Mar 2022 : Case reportAcute Limb Ischemia After Self-Injection of Crushed Morphine Tablets into the Radial Artery: Role of Infrar...
Am J Case Rep 2022; 23:e935336