22 October 2010
Autoimmune pancreatitis masquerading as distal cholangiocarcinoma: A case series of two cases
Rebecca S. Lewis, Haris A. Khwaja, Andrew Wotherspoon, Jeremy N. Thompson, Aamir Z. KhanAm J Case Rep 2010; 11:182-185 :: ID: 881209
Abstract
Background: Autoimmune pancreatitis (AIP) is a rare but distinct form of the disease with manifestations both within the pancreas and outside. Autoimmune pancreatitis can present with extrahepatic strictures which can be difficult to distinguish from malignant strictures, including cholangiocarcinoma. Elevated serum IgG4 levels are a feature of autoimmune pancreatitis and histologically the disease is characterised by a significant periductal lymphoplasmacytic infiltration rich in IgG4 positive cells.
Case Report: The following two cases represent the different treatment options available to patients presenting with malignant bile duct strictures thought to be cholangiocarcinoma which eventually proved to be due to autoimmune pancreatitis. Patient 1 is a 62 year old gentleman of South American descent, and patient 2 is a 72 year old Caucasian gentleman.
Conclusions: Pre-operative diagnosis in autoimmune-related bile duct strictures is important as it may negate the need for major complex surgery.
Keywords: autoimmune pancreatitis, Cholangiocarcinoma, pancreatic cancer
In Press
Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.945539
Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.945795
Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.946588
Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.946011
Most Viewed Current Articles
21 Jun 2024 : Case report
88,761
DOI :10.12659/AJCR.944371
Am J Case Rep 2024; 25:e944371
07 Mar 2024 : Case report
50,081
DOI :10.12659/AJCR.943133
Am J Case Rep 2024; 25:e943133
20 Nov 2023 : Case report
25,336
DOI :10.12659/AJCR.941424
Am J Case Rep 2023; 24:e941424
18 Feb 2024 : Case report
22,657
DOI :10.12659/AJCR.943030
Am J Case Rep 2024; 25:e943030