Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

08 November 2011

Cutaneous Langerhans cell histiocytosis: Report of two cases

Sharma Utsav, Songmei Geng

DOI: 10.12659/AJCR.882097

Am J Case Rep 2011; 12:154-158

Abstract

Abstract
Background: Langerhans cell histiocytosis (LCH) is a rare proliferative disorder of Langerhans cells, with a broad spectrum of clinical manifestation and prognosis. Here, we present 2 cases of cutaneous LCH in young children with good prognosis.
Case Report: A 6-month-old girl showed generalized multiple reddish-brown papules with crust over the trunk. The second patient was a boy aged 2.5 years who also presented with generalized papules with crust and ulcers over the trunk and was treated for eczema and psoriasis with no improvement. In both cases, routine laboratory and radiological examinations were normal, and skin biopsies revealed atrophic epidermis and a dense infiltration of large histiocytic cells with eosinophilic cytoplasm and reniform nuclei. The histiocytes were positive for S100 and CD1a, thus confirming the diagnosis of LCH. Both patients were prescribed chemotherapy including prednisone, vincristine, and azathioprine for 6 months.
Conclusions: Through this case report, we wish to emphasize the importance of both histopathological and immunohistochemical confirmation for the diagnosis of cutaneous manifestations of LCH, as well as recommending a long-term follow-up to monitor recovery and evidence of relapse.

Keywords: langerhans cell histiocytosis, cutaneous, children

Add Comment 0 Comments

In Press

Case report  USA

Pneumococcal Endocarditis, Sepsis, and Meningitis in an Immunocompromised Patient: A Case Study

Am J Case Rep In Press; DOI: 10.12659/AJCR.945915  

Case report  USA

Efficacy of Cold Atmospheric Plasma in Chronic Diabetic Foot Ulcer Management: A Case Report

Am J Case Rep In Press; DOI: 10.12659/AJCR.945462  

Case report  Taiwan

Uncommon Cardiac Perforation and Lead Displacement After Pacemaker Implantation: A Case Study and Diagnosti...

Am J Case Rep In Press; DOI: 10.12659/AJCR.945008  

Case report  Bulgaria

Diagnostic Challenges in Malignant Hyperthermia and Anesthesia-Induced Rhabdomyolysis: A Case Study

Am J Case Rep In Press; DOI: 10.12659/AJCR.946306  

Most Viewed Current Articles

21 Jun 2024 : Case report  China (mainland) 78,462

Intracranial Parasitic Fetus in a Living Infant: A Case Study with Surgical Intervention and Prognosis Anal...

DOI :10.12659/AJCR.944371

Am J Case Rep 2024; 25:e944371

0:00

07 Mar 2024 : Case report  USA 46,330

Neurocysticercosis Presenting as Migraine in the United States

DOI :10.12659/AJCR.943133

Am J Case Rep 2024; 25:e943133

0:00

10 Jan 2022 : Case report  Germany 33,075

A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...

DOI :10.12659/AJCR.935263

Am J Case Rep 2022; 23:e935263

0:00

23 Feb 2022 : Case report  USA 21,596

Penile Necrosis Associated with Local Intravenous Injection of Cocaine

DOI :10.12659/AJCR.935250

Am J Case Rep 2022; 23:e935250

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923