27 April 2026
: Case report
[In Press] A 44-Year-Old Male Manual Laborer With Nonunion of a Femoral Neck Fracture Treated With Ultrasound-Guided Percutaneous Injections of Platelet-Rich Plasma: A Case Report
Unusual or unexpected effect of treatment
Zhi Qiu1ABCDEF, Yanyan Ma1B, Hongju Liu1AEGDOI: 10.12659/AJCR.952788
Am J Case Rep In Press; DOI: 10.12659/AJCR.952788
Available online: 2026-04-27, In Press, Corrected Proof
Publication in the "In-Press" formula aims at speeding up the public availability of the pending manuscript while waiting for the final publication. The assigned DOI number is active and citable. The availability of the article in the Medline, PubMed and PMC databases as well as Web of Science will be obtained after the final publication according to the journal schedule
Abstract
BACKGROUND
Femoral neck fractures are prone to nonunion due to compromised vascular supply. While surgical revision remains the standard of care, biological approaches such as platelet-rich plasma (PRP), a concentrate rich in growth factors that enhance bone healing, offer a less invasive option. This report describes the case of a 44-year-old man, who worked as a manual laborer, with a femoral neck fracture nonunion who refused further surgery and was treated with ultrasound-guided percutaneous injections of PRP.
CASE REPORT
Nine months after undergoing internal fixation for a complex hip fracture, a 44-year-old man presented with persistent right hip pain and gait impairment. Radiographic evaluation confirmed the diagnosis of an oligotrophic nonunion of the femoral neck. The patient declined surgical revision, and a nonsurgical biological intervention was pursued. This consisted of 3 ultrasound-guided percutaneous injections of autologous PRP administered at 1- to 2-week intervals, followed by a structured, phased rehabilitation protocol. Over the ensuing 7 months, serial radiographic follow-up demonstrated progressive bony union. The treatment resulted in complete resolution of pain at rest, minimal pain on weight-bearing, and a successful return to unassisted walking and light work. No adverse events were reported.
CONCLUSIONS
This case demonstrates that a series of ultrasound-guided percutaneous PRP injections can serve as a successful, minimally invasive, non‑surgical alternative for promoting union in selected cases of femoral neck nonunion, potentially allowing patients to avoid revision surgery.
Keywords: Case Reports; Femoral Neck Fractures; Fracture Healing; Orthopedics; Platelet-Rich Plasma; Ultrasonography
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