Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

23 August 2026 : Case report  China

[In Press] Case Report: Botulinum Toxin Type A Injection for Bruxism Following Left Basal Ganglia Hemorrhage

Unusual or unexpected effect of treatment

Jialing Wang1ABEF, Xudong Zhu2CFG, Yanjie Fu1ACD, Ya Zheng1ACD

DOI: 10.12659/AJCR.953163

Am J Case Rep In Press; DOI: 10.12659/AJCR.953163  

Available online: 2026-08-23, In Press, Corrected Proof

Publication in the "In-Press" formula aims at speeding up the public availability of the pending manuscript while waiting for the final publication. The assigned DOI number is active and citable. The availability of the article in the Medline, PubMed and PMC databases as well as Web of Science will be obtained after the final publication according to the journal schedule

Abstract

BACKGROUND
Post‑stroke bruxism is an underrecognized complication that may impair oral function, cause orofacial pain, and negatively impact rehabilitation outcomes. Botulinum toxin type A (BoNT‑A) has been reported for bruxism, but its application in post‑stroke populations remains sparsely documented. This case describes the assessment and treatment of bruxism following cerebral hemorrhage, utilizing the Standardized Tool for the Assessment of Bruxism (STAB) as a structured multidimensional framework.
CASE REPORT
A 40-year-old man developed bruxism during recovery from a massive left hemispheric intracerebral hemorrhage after decompressive craniectomy and hematoma evacuation. About 3 months after admission, he began to exhibit bilateral masseter muscle hypertrophy with marked tenderness, temporomandibular joint pain, and drooling from the right mouth corner, with no prior history of bruxism. STAB-based evaluation yielded the following Axis A findings: Subject-based assessment revealed nocturnal grinding reported by caregivers. Clinically based assessment revealed bilateral masseter hypertrophy, tenderness on palpation, and dental wear. Instrument-based assessment (surface electromyography used for injection guidance) confirmed increased masseter muscle activity at rest and during clenching. Symptoms were refractory to occlusal splint therapy combined with hot compresses. At 48 hours after electromyography-guided injection into the bilateral masseter muscles (50 U per side, divided into 3 sites per side), muscle tension and tenderness were markedly reduced, and clinical improvement persisted at 6-month follow-up.
CONCLUSIONS
In this single case, BoNT‑A injection was temporally associated with symptom relief in post-stroke bruxism. STAB provided a structured multidimensional assessment framework. These descriptive findings have limited generalizability. Controlled studies are needed to establish the efficacy and safety of this intervention in the post‑stroke population.

Keywords: Botulinum Toxins, Type A; Bruxism; Cerebral Hemorrhage

In Press

Case report  Saudi Arabia

Three Pediatric Cases of Accidental Lip Entrapment, Laceration, and Tongue Injury From Motorized Electric N...

Am J Case Rep In Press; DOI: 10.12659/AJCR.953929  

Case report  Thailand

Recurrent Intravenous Contrast-Induced Submandibular Sialadenitis: A Case Report and Literature Review

Am J Case Rep In Press; DOI: 10.12659/AJCR.953439  

Case report  USA

Airway Emergency in a Primigravida Associated With Paradoxical Vocal Fold Motion and Placental Abruption Le...

Am J Case Rep In Press; DOI: 10.12659/AJCR.953653  

Case report  Indonesia

Intravitreal Onchocerca sp. With Concomitant Cerebral MRI Lesion: A Case Report

Am J Case Rep In Press; DOI: 10.12659/AJCR.952921  

Most Viewed Current Articles

07 Dec 2021 : Case report  USA 22,772,684

Edwardsiella tarda: A Classic Presentation of a Rare Fatal Infection, with Possible New Background Risk Fac...

DOI :10.12659/AJCR.934347

Am J Case Rep 2021; 22:e934347

06 Dec 2021 : Case report  Brazil 178,948

Lipedema Can Be Treated Non-Surgically: A Report of 5 Cases

DOI :10.12659/AJCR.934406

Am J Case Rep 2021; 22:e934406

21 Jun 2024 : Case report  China (mainland) 122,859

Intracranial Parasitic Fetus in a Living Infant: A Case Study with Surgical Intervention and Prognosis Anal...

DOI :10.12659/AJCR.944371

Am J Case Rep 2024; 25:e944371

0:00

07 Mar 2024 : Case report  USA 67,338

Neurocysticercosis Presenting as Migraine in the United States

DOI :10.12659/AJCR.943133

Am J Case Rep 2024; 25:e943133

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923