BACKGROUND: Zinner syndrome is a rare congenital anomaly of the male genitourinary system, characterized by the classic triad of features: a seminal vesicle cyst, unilateral renal agenesis, and vas deferens obstruction. This article presents a clinical case of a 36-year-old patient with this rare condition and describes the results of his successful laparoscopic surgical treatment.

CASE REPORT: A 36-year-old man with a 2-year history of infertility and chronic pelvic pain received a diagnosis of Zinner syndrome, characterized by the triad of left renal agenesis, ipsilateral ureteral atresia, and a large seminal vesicle cyst. He underwent successful laparoscopic excision of the cyst. The cyst contents (approximately 120 mL of light-brown fluid) were aspirated, followed by meticulous enucleation. The cyst, remnant seminal vesicle tissue, and distal atretic ureter (3 cm) were completely resected. Histopathological examination confirmed a benign, multilocular cyst lined by columnar epithelium with glandular metaplasia and chronic inflammation, with no evidence of malignancy. The postoperative course was uneventful. At 3-month follow-up, the patient reported complete resolution of pain and normalized urination. Semen analysis showed significant improvement: ejaculate volume increased to 1.6 mL, sperm concentration to 1.4×10⁷/mL, and progressive motility to 35%, indicating partial recovery of ejaculatory function. The case demonstrates that laparoscopic surgery is an effective treatment for Zinner syndrome, alleviating symptoms and potentially improving fertility parameters.

CONCLUSIONS: This case highlights the importance of timely recognition of Zinner syndrome, especially in patients with unilateral renal agenesis and pelvic pain, and demonstrates the effectiveness of the laparoscopic approach as a method of choice in the symptomatic course of this pathology.

Keywords: Zinner Syndrome, laparoscopic surgery, renal agenesis, seminal vesicle cyst, male infertility, case report