Challenging differential diagnosis
17 Dec 2025 : Case report 
COVID-19-Associated MDA5-Mediated Necrotizing Myositis
Sarah Steadman, Amit Sikder, Harsh R. Desai 
, Bradley Collins , Tiffany Baker, Julie Worthington
DOI: 10.12659/AJCR.949788
Am J Case Rep 2025; 26:e949788
1,196 2,437 0
17 Dec 2025 : Case report
COVID-19-Associated MDA5-Mediated Necrotizing Myositis
Sarah Steadman, Amit Sikder, Harsh R. Desai , Bradley Collins , Tiffany Baker, Julie Worthington
DOI: 10.12659/AJCR.949788
Am J Case Rep 2025; 26:e949788
1196 2437 0
23 Dec 2025 : Case report 
Platypnea-Orthodeoxia Syndrome Associated With a Right-to-Left Cardiac Shunt Detected by Lung Perfusion Scintigraphy
Yusuke Nakano , Hirohiko Ando, Akinori Satake, Reiji Goto, Kentaro Mukai, Tetsuya Amano
DOI: 10.12659/AJCR.949642
Am J Case Rep 2025; 26:e949642
672 1,351 0
23 Dec 2025 : Case report
Platypnea-Orthodeoxia Syndrome Associated With a Right-to-Left Cardiac Shunt Detected by Lung Perfusion Scintigraphy
Yusuke Nakano , Hirohiko Ando, Akinori Satake, Reiji Goto, Kentaro Mukai, Tetsuya Amano
DOI: 10.12659/AJCR.949642
Am J Case Rep 2025; 26:e949642
672 1351 0
22 Dec 2025 : Case report 
Asymptomatic Lung Adenocarcinoma With Cardiac Metastasis at Initial Diagnosis: A Case Report
Tianyu Jin, Yongzhong Jiang, Yong Song
DOI: 10.12659/AJCR.951223
Am J Case Rep 2025; 26:e951223
731 1,732 0
22 Dec 2025 : Case report
Asymptomatic Lung Adenocarcinoma With Cardiac Metastasis at Initial Diagnosis: A Case Report
Tianyu Jin, Yongzhong Jiang, Yong Song
DOI: 10.12659/AJCR.951223
Am J Case Rep 2025; 26:e951223
731 1732 0
21 Dec 2025 : Case report
Allergic Bronchopulmonary Aspergillosis Presenting With Pulmonary Solid Lesions and Elevated Serum Carcinoembryonic Antigen Mimicking Lung Cancer
Heling Wu, Tiange Qu, Shenwen Yi, Jun Xu, Fei Yu, Liang Ye
DOI: 10.12659/AJCR.947770
Am J Case Rep 2025; 26:e947770
883 1,643 0
21 Dec 2025 : Case report
Allergic Bronchopulmonary Aspergillosis Presenting With Pulmonary Solid Lesions and Elevated Serum Carcinoembryonic Antigen Mimicking Lung Cancer
Heling Wu, Tiange Qu, Shenwen Yi, Jun Xu, Fei Yu, Liang Ye
DOI: 10.12659/AJCR.947770
Am J Case Rep 2025; 26:e947770
883 1643 0
20 Dec 2025 : Case report
Diagnostic Challenges of Abdominal Tumors Without Typical Imaging Features: From Misdiagnosis of Pancreatic Cystadenoma to Adrenal Pheochromocytoma and the Intraoperative Response
Haoyang Huang , Dingwei Xu , Zhangbin Chen, Jie Huang
DOI: 10.12659/AJCR.950574
Am J Case Rep 2025; 26:e950574
743 980 0
20 Dec 2025 : Case report
Diagnostic Challenges of Abdominal Tumors Without Typical Imaging Features: From Misdiagnosis of Pancreatic Cystadenoma to Adrenal Pheochromocytoma and the Intraoperative Response
Haoyang Huang , Dingwei Xu , Zhangbin Chen, Jie Huang
DOI: 10.12659/AJCR.950574
Am J Case Rep 2025; 26:e950574
743 980 0
16 Dec 2025 : Case report
Subdural Empyema and Pneumocephalus From Chronic Polypoid Sinusitis in an Elderly Woman With Rapid Neurological Recovery: A Report of a Rare Case
John Martinez, Elizabeth Nagidi, Mark Rigby , Lina Ataya, Aftab Macksood, Ghiath Bayasi, Kelsee Rotondo
DOI: 10.12659/AJCR.949999
Am J Case Rep 2025; 26:e949999
678 1,369 0
16 Dec 2025 : Case report
Subdural Empyema and Pneumocephalus From Chronic Polypoid Sinusitis in an Elderly Woman With Rapid Neurological Recovery: A Report of a Rare Case
John Martinez, Elizabeth Nagidi, Mark Rigby , Lina Ataya, Aftab Macksood, Ghiath Bayasi, Kelsee Rotondo
DOI: 10.12659/AJCR.949999
Am J Case Rep 2025; 26:e949999
678 1369 0
19 Dec 2025 : Case report
Primary Orbital Lymphoma Manifesting as Increased Intraocular Pressure: A Case Report
Miaomiao Sun, Zhaohui Xiong, Yincong Xu, Zhongyou Zhou, Jiale Wu, Jiangzhou Han, Lina Zhao
DOI: 10.12659/AJCR.951048
Am J Case Rep 2025; 26:e951048
891 1,510 0
19 Dec 2025 : Case report
Primary Orbital Lymphoma Manifesting as Increased Intraocular Pressure: A Case Report
Miaomiao Sun, Zhaohui Xiong, Yincong Xu, Zhongyou Zhou, Jiale Wu, Jiangzhou Han, Lina Zhao
DOI: 10.12659/AJCR.951048
Am J Case Rep 2025; 26:e951048
891 1510 0
21 Nov 2025 : Case report 
Left-Sided Perforated Appendicitis in an Elderly Man with Intestinal Malrotation: A Case Report
Jose Samaniego-Burneo , Jordan Llerena-Velastegui , Alberto Gordillo-Calero, Brenda Santamaria-Penafiel, Natalia Lopez-Yepez
DOI: 10.12659/AJCR.949960
Am J Case Rep 2025; 26:e949960
733 1,205 0
21 Nov 2025 : Case report
Left-Sided Perforated Appendicitis in an Elderly Man with Intestinal Malrotation: A Case Report
Jose Samaniego-Burneo , Jordan Llerena-Velastegui , Alberto Gordillo-Calero, Brenda Santamaria-Penafiel, Natalia Lopez-Yepez
DOI: 10.12659/AJCR.949960
Am J Case Rep 2025; 26:e949960
733 1205 0
18 Dec 2025 : Case report
Drug-Induced Lupus Erythematosus After 14 Years of Carbamazepine Use in a Patient With Neuromyelitis Optica Spectrum Disorder: A Case Report
Naho Ayuzawa-Takeda, Keisuke Saito, Hidetoshi Yanagida, Tomoko Oeda
DOI: 10.12659/AJCR.949233
Am J Case Rep 2025; 26:e949233
972 3,263 0
18 Dec 2025 : Case report
Drug-Induced Lupus Erythematosus After 14 Years of Carbamazepine Use in a Patient With Neuromyelitis Optica Spectrum Disorder: A Case Report
Naho Ayuzawa-Takeda, Keisuke Saito, Hidetoshi Yanagida, Tomoko Oeda
DOI: 10.12659/AJCR.949233
Am J Case Rep 2025; 26:e949233
972 3263 0
17 Dec 2025 : Case report
Splenic Hamartoma Diagnosed and Treated by Laparoscopic Splenectomy Associated With a Minimal Suprapubic Approach
Hikaru Ohtani, Tomohide Hori, Shigeki Nakayama, Satoru Umegae, Takao Iwanaga, Ryutaro Nishikawa, Takahiro Shimoyama, Sakurako Suzuki, Shigehito Nakashima, Takayuki Yamamoto
DOI: 10.12659/AJCR.950597
Am J Case Rep 2025; 26:e950597
652 1,032 0
17 Dec 2025 : Case report
Splenic Hamartoma Diagnosed and Treated by Laparoscopic Splenectomy Associated With a Minimal Suprapubic Approach
Hikaru Ohtani, Tomohide Hori, Shigeki Nakayama, Satoru Umegae, Takao Iwanaga, Ryutaro Nishikawa, Takahiro Shimoyama, Sakurako Suzuki, Shigehito Nakashima, Takayuki Yamamoto
DOI: 10.12659/AJCR.950597
Am J Case Rep 2025; 26:e950597
652 1032 0
15 Dec 2025 : Case report 
Compartment Syndrome Secondary to Phlegmasia Cerulea Dolens in a Patient With Crohn’s Disease
Saad Mohammed Alshahrani , Raghad Ibrahim Alkoblan, Reem Abdulaziz Alturki, Shahad Mohammed Alashgar
DOI: 10.12659/AJCR.948950
Am J Case Rep 2025; 26:e948950
677 1,029 0
15 Dec 2025 : Case report
Compartment Syndrome Secondary to Phlegmasia Cerulea Dolens in a Patient With Crohn’s Disease
Saad Mohammed Alshahrani , Raghad Ibrahim Alkoblan, Reem Abdulaziz Alturki, Shahad Mohammed Alashgar
DOI: 10.12659/AJCR.948950
Am J Case Rep 2025; 26:e948950
677 1029 0
16 Dec 2025 : Case report
Electronic Gastroscopy in Identifying Hidden Tonsillar Foreign Bodies: A Case of a Completely Embedded Sunflower Seed Shell
Deng Liang
DOI: 10.12659/AJCR.949052
Am J Case Rep 2025; 26:e949052
652 986 0
16 Dec 2025 : Case report
Electronic Gastroscopy in Identifying Hidden Tonsillar Foreign Bodies: A Case of a Completely Embedded Sunflower Seed Shell
Deng Liang
DOI: 10.12659/AJCR.949052
Am J Case Rep 2025; 26:e949052
652 986 0
15 Dec 2025 : Case report
Primary Pulmonary Osteosarcoma Presenting as a 1.7-cm Subpleural Nodule in a 61-Year-Old Man: A Case Report
Xin Yang, Wen Guang Zhao, Chao Gao, Sheng Lin
DOI: 10.12659/AJCR.949034
Am J Case Rep 2025; 26:e949034
734 942 0
15 Dec 2025 : Case report
Primary Pulmonary Osteosarcoma Presenting as a 1.7-cm Subpleural Nodule in a 61-Year-Old Man: A Case Report
Xin Yang, Wen Guang Zhao, Chao Gao, Sheng Lin
DOI: 10.12659/AJCR.949034
Am J Case Rep 2025; 26:e949034
734 942 0
12 Dec 2025 : Case report 
Unpredictable Evolution of Pilocytic Astrocytoma in Adults: A Case Series and Diagnostic Challenges
Anamaria Sincu, Cristian-Ionut Orasanu , Raluca Ioana Voda , Madalina Bosoteanu , Manuela Enciu , Sorin Vamesu , Sinziana Andra Ghitoi, Mariana Deacu
DOI: 10.12659/AJCR.947774
Am J Case Rep 2025; 26:e947774
921 3,827 0
12 Dec 2025 : Case report
Unpredictable Evolution of Pilocytic Astrocytoma in Adults: A Case Series and Diagnostic Challenges
Anamaria Sincu, Cristian-Ionut Orasanu , Raluca Ioana Voda , Madalina Bosoteanu , Manuela Enciu , Sorin Vamesu , Sinziana Andra Ghitoi, Mariana Deacu
DOI: 10.12659/AJCR.947774
Am J Case Rep 2025; 26:e947774
921 3827 0
14 Dec 2025 : Case report
Bruton’s Agammaglobulinemia: Case Series and Literature Review From King Fahad Central Hospital, Jizan, Saudi Arabia
Ahmed Shamakhi, Nabil Dhayhi, Shatha Matabi, Manal Maashi, Abdullah Dhaifallah Hamdi, Bander Ali, Fadhel Hazazi, Abdullah H. Alhamoud
DOI: 10.12659/AJCR.949936
Am J Case Rep 2025; 26:e949936
962 2,513 0
14 Dec 2025 : Case report
Bruton’s Agammaglobulinemia: Case Series and Literature Review From King Fahad Central Hospital, Jizan, Saudi Arabia
Ahmed Shamakhi, Nabil Dhayhi, Shatha Matabi, Manal Maashi, Abdullah Dhaifallah Hamdi, Bander Ali, Fadhel Hazazi, Abdullah H. Alhamoud
DOI: 10.12659/AJCR.949936
Am J Case Rep 2025; 26:e949936
962 2513 0
11 Dec 2025 : Case report 
A 60-Year-Old Man with an Incidental Finding of an Asymptomatic Aneurysm of the Right Gastroepiploic Artery Managed by Laparoscopic Resection
Maksymilian Baryła , Paweł Kazimierz Ziemiański
DOI: 10.12659/AJCR.948020
Am J Case Rep 2025; 26:e948020
668 999 0
11 Dec 2025 : Case report
A 60-Year-Old Man with an Incidental Finding of an Asymptomatic Aneurysm of the Right Gastroepiploic Artery Managed by Laparoscopic Resection
Maksymilian Baryła , Paweł Kazimierz Ziemiański
DOI: 10.12659/AJCR.948020
Am J Case Rep 2025; 26:e948020
668 999 0
30 Nov 2025 : Case report
Afebrile HSV-2 Encephalitis with Radiographic Atypia and Minimal Systemic Inflammation: A Case Report
Shunsuke Kondo , Wejdan Abo Qayas, Osama Hasan, Rachel Haide N. Tacata, Matthew W. Kobylinski, Lorrance Majewski
DOI: 10.12659/AJCR.950444
Am J Case Rep 2025; 26:e950444
798 1,742 0
30 Nov 2025 : Case report
Afebrile HSV-2 Encephalitis with Radiographic Atypia and Minimal Systemic Inflammation: A Case Report
Shunsuke Kondo , Wejdan Abo Qayas, Osama Hasan, Rachel Haide N. Tacata, Matthew W. Kobylinski, Lorrance Majewski
DOI: 10.12659/AJCR.950444
Am J Case Rep 2025; 26:e950444
798 1742 0
07 Dec 2025 : Case report 
Campfire Smoke as a Plausible Trigger for Vasospastic Angina: Insights From a Case Report
Gabrielle Denault, Anne-Sophie Lê, Emad Tahir, Stéphane Perron
DOI: 10.12659/AJCR.949363
Am J Case Rep 2025; 26:e949363
853 2,708 0
07 Dec 2025 : Case report
Campfire Smoke as a Plausible Trigger for Vasospastic Angina: Insights From a Case Report
Gabrielle Denault, Anne-Sophie Lê, Emad Tahir, Stéphane Perron
DOI: 10.12659/AJCR.949363
Am J Case Rep 2025; 26:e949363
853 2708 0
10 Dec 2025 : Case report 
Isolated Transient Neonatal Ascites in a Preterm Infant Born to a Mother with Mirror Syndrome: A Case Report
Mo’ath Abu Hamdeh, Rasmea Mohammad Asad, Zeidan Abdalsalam, Mohammad Maraqah, Lema Saleh Khaled Jaber, Mai M.R. Rostom, Majed Methqal Abu Jaish
DOI: 10.12659/AJCR.949587
Am J Case Rep 2025; 26:e949587
861 1,856 0
10 Dec 2025 : Case report
Isolated Transient Neonatal Ascites in a Preterm Infant Born to a Mother with Mirror Syndrome: A Case Report
Mo’ath Abu Hamdeh, Rasmea Mohammad Asad, Zeidan Abdalsalam, Mohammad Maraqah, Lema Saleh Khaled Jaber, Mai M.R. Rostom, Majed Methqal Abu Jaish
DOI: 10.12659/AJCR.949587
Am J Case Rep 2025; 26:e949587
861 1856 0
03 Dec 2025 : Case report
Endoscopic Retrieval of Ingested Button Battery From a Colonic Diverticulum in an Alzheimer’s Patient: A Case Report
Kazuko Hizukuri, Yasuhiko Fujita, Teruyoshi Amagai
DOI: 10.12659/AJCR.949004
Am J Case Rep 2025; 26:e949004
575 980 0
03 Dec 2025 : Case report
Endoscopic Retrieval of Ingested Button Battery From a Colonic Diverticulum in an Alzheimer’s Patient: A Case Report
Kazuko Hizukuri, Yasuhiko Fujita, Teruyoshi Amagai
DOI: 10.12659/AJCR.949004
Am J Case Rep 2025; 26:e949004
575 980 0
04 Dec 2025 : Case report 
A 27-Year-Old Man with Chronic Traumatic Pancreatic Fistula Managed with Percutaneous Microwave Ablation
Raphael AlSarma, Abdel-Rahman Salameh, Talal Sultan M. Althobity, Farooq Bacha, Mohamed Karji Almarzooqi, Iyad Hassan
DOI: 10.12659/AJCR.949541
Am J Case Rep 2025; 26:e949541
648 1,119 0
04 Dec 2025 : Case report
A 27-Year-Old Man with Chronic Traumatic Pancreatic Fistula Managed with Percutaneous Microwave Ablation
Raphael AlSarma, Abdel-Rahman Salameh, Talal Sultan M. Althobity, Farooq Bacha, Mohamed Karji Almarzooqi, Iyad Hassan
DOI: 10.12659/AJCR.949541
Am J Case Rep 2025; 26:e949541
648 1119 0
01 Dec 2025 : Case report
Late-Onset Mesh Infection 10 Years After Right Inguinal Hernia Repair: A Case Report
Ryoichi Shimizu , Masahito Uji, Hideo Matsubara, Yasutomo Miura, Yudai Aoki, Takahiro Maehata, Kazumasa Matsuoka, Yasuji Mokuno
DOI: 10.12659/AJCR.949941
Am J Case Rep 2025; 26:e949941
821 3,275 0
01 Dec 2025 : Case report
Late-Onset Mesh Infection 10 Years After Right Inguinal Hernia Repair: A Case Report
Ryoichi Shimizu , Masahito Uji, Hideo Matsubara, Yasutomo Miura, Yudai Aoki, Takahiro Maehata, Kazumasa Matsuoka, Yasuji Mokuno
DOI: 10.12659/AJCR.949941
Am J Case Rep 2025; 26:e949941
821 3275 0
09 Dec 2025 : Case report
A Rare Case of Emphysematous Pyelonephritis Following Retrograde Intrarenal Surgery in an Elderly Man
Weiyong Zhong , Feihong Xu , Shujiang Ye, Yu Liu, Wei Zhao, Zhenquan Lu, Lin Xiong, Xiang Xu
DOI: 10.12659/AJCR.949018
Am J Case Rep 2025; 26:e949018
717 1,189 0
09 Dec 2025 : Case report
A Rare Case of Emphysematous Pyelonephritis Following Retrograde Intrarenal Surgery in an Elderly Man
Weiyong Zhong , Feihong Xu , Shujiang Ye, Yu Liu, Wei Zhao, Zhenquan Lu, Lin Xiong, Xiang Xu
DOI: 10.12659/AJCR.949018
Am J Case Rep 2025; 26:e949018
717 1189 0
29 Nov 2025 : Case report 
Mixed Cryoglobulinemia in the Setting of Monoclonal B-Cell Lymphocytosis and Monoclonal Gammopathy of Unknown Significance: A Case Report
Eleni Bouziani , Luisa Ladel, Aaron James Stonestrom
DOI: 10.12659/AJCR.949597
Am J Case Rep 2025; 26:e949597
793 1,792 0
29 Nov 2025 : Case report
Mixed Cryoglobulinemia in the Setting of Monoclonal B-Cell Lymphocytosis and Monoclonal Gammopathy of Unknown Significance: A Case Report
Eleni Bouziani , Luisa Ladel, Aaron James Stonestrom
DOI: 10.12659/AJCR.949597
Am J Case Rep 2025; 26:e949597
793 1792 0
07 Dec 2025 : Case report 
Acute Kidney Injury from Mononuclear Cell-Predominated Interstitial Nephritis After Introduction of a Glucagon-Like Peptide-1 Receptor Agonist: A Case Report
Raweekarn Itsathitpaisarn, Nattavong Suksawad, Watsapol Wongwikrom, Jerasit Surintrspanont , Thana Thongsricome
DOI: 10.12659/AJCR.949913
Am J Case Rep 2025; 26:e949913
1,006 2,173 0
07 Dec 2025 : Case report
Acute Kidney Injury from Mononuclear Cell-Predominated Interstitial Nephritis After Introduction of a Glucagon-Like Peptide-1 Receptor Agonist: A Case Report
Raweekarn Itsathitpaisarn, Nattavong Suksawad, Watsapol Wongwikrom, Jerasit Surintrspanont , Thana Thongsricome
DOI: 10.12659/AJCR.949913
Am J Case Rep 2025; 26:e949913
1006 2173 0
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Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.953192
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Am J Case Rep In Press; DOI: 10.12659/AJCR.953608
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