Challenging differential diagnosis
19 Dec 2025 : Case report 
Primary Orbital Lymphoma Manifesting as Increased Intraocular Pressure: A Case Report
Miaomiao Sun, Zhaohui Xiong, Yincong Xu, Zhongyou Zhou, Jiale Wu, Jiangzhou Han, Lina Zhao
DOI: 10.12659/AJCR.951048
Am J Case Rep 2025; 26:e951048
949 1,884 0
19 Dec 2025 : Case report
Primary Orbital Lymphoma Manifesting as Increased Intraocular Pressure: A Case Report
Miaomiao Sun, Zhaohui Xiong, Yincong Xu, Zhongyou Zhou, Jiale Wu, Jiangzhou Han, Lina Zhao
DOI: 10.12659/AJCR.951048
Am J Case Rep 2025; 26:e951048
949 1884 0
21 Nov 2025 : Case report 
Left-Sided Perforated Appendicitis in an Elderly Man with Intestinal Malrotation: A Case Report
Jose Samaniego-Burneo 
, Jordan Llerena-Velastegui , Alberto Gordillo-Calero, Brenda Santamaria-Penafiel, Natalia Lopez-Yepez
DOI: 10.12659/AJCR.949960
Am J Case Rep 2025; 26:e949960
775 1,275 0
21 Nov 2025 : Case report
Left-Sided Perforated Appendicitis in an Elderly Man with Intestinal Malrotation: A Case Report
Jose Samaniego-Burneo , Jordan Llerena-Velastegui , Alberto Gordillo-Calero, Brenda Santamaria-Penafiel, Natalia Lopez-Yepez
DOI: 10.12659/AJCR.949960
Am J Case Rep 2025; 26:e949960
775 1275 0
18 Dec 2025 : Case report 
Drug-Induced Lupus Erythematosus After 14 Years of Carbamazepine Use in a Patient With Neuromyelitis Optica Spectrum Disorder: A Case Report
Naho Ayuzawa-Takeda, Keisuke Saito, Hidetoshi Yanagida, Tomoko Oeda
DOI: 10.12659/AJCR.949233
Am J Case Rep 2025; 26:e949233
1,052 3,619 0
18 Dec 2025 : Case report
Drug-Induced Lupus Erythematosus After 14 Years of Carbamazepine Use in a Patient With Neuromyelitis Optica Spectrum Disorder: A Case Report
Naho Ayuzawa-Takeda, Keisuke Saito, Hidetoshi Yanagida, Tomoko Oeda
DOI: 10.12659/AJCR.949233
Am J Case Rep 2025; 26:e949233
1052 3619 0
17 Dec 2025 : Case report
Splenic Hamartoma Diagnosed and Treated by Laparoscopic Splenectomy Associated With a Minimal Suprapubic Approach
Hikaru Ohtani, Tomohide Hori, Shigeki Nakayama, Satoru Umegae, Takao Iwanaga, Ryutaro Nishikawa, Takahiro Shimoyama, Sakurako Suzuki, Shigehito Nakashima, Takayuki Yamamoto
DOI: 10.12659/AJCR.950597
Am J Case Rep 2025; 26:e950597
703 1,146 0
17 Dec 2025 : Case report
Splenic Hamartoma Diagnosed and Treated by Laparoscopic Splenectomy Associated With a Minimal Suprapubic Approach
Hikaru Ohtani, Tomohide Hori, Shigeki Nakayama, Satoru Umegae, Takao Iwanaga, Ryutaro Nishikawa, Takahiro Shimoyama, Sakurako Suzuki, Shigehito Nakashima, Takayuki Yamamoto
DOI: 10.12659/AJCR.950597
Am J Case Rep 2025; 26:e950597
703 1146 0
15 Dec 2025 : Case report 
Compartment Syndrome Secondary to Phlegmasia Cerulea Dolens in a Patient With Crohn’s Disease
Saad Mohammed Alshahrani , Raghad Ibrahim Alkoblan, Reem Abdulaziz Alturki, Shahad Mohammed Alashgar
DOI: 10.12659/AJCR.948950
Am J Case Rep 2025; 26:e948950
747 1,122 0
15 Dec 2025 : Case report
Compartment Syndrome Secondary to Phlegmasia Cerulea Dolens in a Patient With Crohn’s Disease
Saad Mohammed Alshahrani , Raghad Ibrahim Alkoblan, Reem Abdulaziz Alturki, Shahad Mohammed Alashgar
DOI: 10.12659/AJCR.948950
Am J Case Rep 2025; 26:e948950
747 1122 0
16 Dec 2025 : Case report
Electronic Gastroscopy in Identifying Hidden Tonsillar Foreign Bodies: A Case of a Completely Embedded Sunflower Seed Shell
Deng Liang
DOI: 10.12659/AJCR.949052
Am J Case Rep 2025; 26:e949052
738 1,165 0
16 Dec 2025 : Case report
Electronic Gastroscopy in Identifying Hidden Tonsillar Foreign Bodies: A Case of a Completely Embedded Sunflower Seed Shell
Deng Liang
DOI: 10.12659/AJCR.949052
Am J Case Rep 2025; 26:e949052
738 1165 0
15 Dec 2025 : Case report
Primary Pulmonary Osteosarcoma Presenting as a 1.7-cm Subpleural Nodule in a 61-Year-Old Man: A Case Report
Xin Yang, Wen Guang Zhao, Chao Gao, Sheng Lin
DOI: 10.12659/AJCR.949034
Am J Case Rep 2025; 26:e949034
789 1,028 0
15 Dec 2025 : Case report
Primary Pulmonary Osteosarcoma Presenting as a 1.7-cm Subpleural Nodule in a 61-Year-Old Man: A Case Report
Xin Yang, Wen Guang Zhao, Chao Gao, Sheng Lin
DOI: 10.12659/AJCR.949034
Am J Case Rep 2025; 26:e949034
789 1028 0
12 Dec 2025 : Case report 
Unpredictable Evolution of Pilocytic Astrocytoma in Adults: A Case Series and Diagnostic Challenges
Anamaria Sincu, Cristian-Ionut Orasanu , Raluca Ioana Voda , Madalina Bosoteanu , Manuela Enciu , Sorin Vamesu , Sinziana Andra Ghitoi, Mariana Deacu
DOI: 10.12659/AJCR.947774
Am J Case Rep 2025; 26:e947774
970 4,369 0
12 Dec 2025 : Case report
Unpredictable Evolution of Pilocytic Astrocytoma in Adults: A Case Series and Diagnostic Challenges
Anamaria Sincu, Cristian-Ionut Orasanu , Raluca Ioana Voda , Madalina Bosoteanu , Manuela Enciu , Sorin Vamesu , Sinziana Andra Ghitoi, Mariana Deacu
DOI: 10.12659/AJCR.947774
Am J Case Rep 2025; 26:e947774
970 4369 0
14 Dec 2025 : Case report
Bruton’s Agammaglobulinemia: Case Series and Literature Review From King Fahad Central Hospital, Jizan, Saudi Arabia
Ahmed Shamakhi, Nabil Dhayhi, Shatha Matabi, Manal Maashi, Abdullah Dhaifallah Hamdi, Bander Ali, Fadhel Hazazi, Abdullah H. Alhamoud
DOI: 10.12659/AJCR.949936
Am J Case Rep 2025; 26:e949936
1,065 3,013 0
14 Dec 2025 : Case report
Bruton’s Agammaglobulinemia: Case Series and Literature Review From King Fahad Central Hospital, Jizan, Saudi Arabia
Ahmed Shamakhi, Nabil Dhayhi, Shatha Matabi, Manal Maashi, Abdullah Dhaifallah Hamdi, Bander Ali, Fadhel Hazazi, Abdullah H. Alhamoud
DOI: 10.12659/AJCR.949936
Am J Case Rep 2025; 26:e949936
1065 3013 0
11 Dec 2025 : Case report 
A 60-Year-Old Man with an Incidental Finding of an Asymptomatic Aneurysm of the Right Gastroepiploic Artery Managed by Laparoscopic Resection
Maksymilian Baryła , Paweł Kazimierz Ziemiański
DOI: 10.12659/AJCR.948020
Am J Case Rep 2025; 26:e948020
735 1,099 0
11 Dec 2025 : Case report
A 60-Year-Old Man with an Incidental Finding of an Asymptomatic Aneurysm of the Right Gastroepiploic Artery Managed by Laparoscopic Resection
Maksymilian Baryła , Paweł Kazimierz Ziemiański
DOI: 10.12659/AJCR.948020
Am J Case Rep 2025; 26:e948020
735 1099 0
30 Nov 2025 : Case report 
Afebrile HSV-2 Encephalitis with Radiographic Atypia and Minimal Systemic Inflammation: A Case Report
Shunsuke Kondo , Wejdan Abo Qayas, Osama Hasan, Rachel Haide N. Tacata, Matthew W. Kobylinski, Lorrance Majewski
DOI: 10.12659/AJCR.950444
Am J Case Rep 2025; 26:e950444
859 2,174 0
30 Nov 2025 : Case report
Afebrile HSV-2 Encephalitis with Radiographic Atypia and Minimal Systemic Inflammation: A Case Report
Shunsuke Kondo , Wejdan Abo Qayas, Osama Hasan, Rachel Haide N. Tacata, Matthew W. Kobylinski, Lorrance Majewski
DOI: 10.12659/AJCR.950444
Am J Case Rep 2025; 26:e950444
859 2174 0
07 Dec 2025 : Case report 
Campfire Smoke as a Plausible Trigger for Vasospastic Angina: Insights From a Case Report
Gabrielle Denault, Anne-Sophie Lê, Emad Tahir, Stéphane Perron
DOI: 10.12659/AJCR.949363
Am J Case Rep 2025; 26:e949363
934 3,017 0
07 Dec 2025 : Case report
Campfire Smoke as a Plausible Trigger for Vasospastic Angina: Insights From a Case Report
Gabrielle Denault, Anne-Sophie Lê, Emad Tahir, Stéphane Perron
DOI: 10.12659/AJCR.949363
Am J Case Rep 2025; 26:e949363
934 3017 0
10 Dec 2025 : Case report 
Isolated Transient Neonatal Ascites in a Preterm Infant Born to a Mother with Mirror Syndrome: A Case Report
Mo’ath Abu Hamdeh, Rasmea Mohammad Asad, Zeidan Abdalsalam, Mohammad Maraqah, Lema Saleh Khaled Jaber, Mai M.R. Rostom, Majed Methqal Abu Jaish
DOI: 10.12659/AJCR.949587
Am J Case Rep 2025; 26:e949587
935 2,051 0
10 Dec 2025 : Case report
Isolated Transient Neonatal Ascites in a Preterm Infant Born to a Mother with Mirror Syndrome: A Case Report
Mo’ath Abu Hamdeh, Rasmea Mohammad Asad, Zeidan Abdalsalam, Mohammad Maraqah, Lema Saleh Khaled Jaber, Mai M.R. Rostom, Majed Methqal Abu Jaish
DOI: 10.12659/AJCR.949587
Am J Case Rep 2025; 26:e949587
935 2051 0
03 Dec 2025 : Case report
Endoscopic Retrieval of Ingested Button Battery From a Colonic Diverticulum in an Alzheimer’s Patient: A Case Report
Kazuko Hizukuri, Yasuhiko Fujita, Teruyoshi Amagai
DOI: 10.12659/AJCR.949004
Am J Case Rep 2025; 26:e949004
626 1,092 0
03 Dec 2025 : Case report
Endoscopic Retrieval of Ingested Button Battery From a Colonic Diverticulum in an Alzheimer’s Patient: A Case Report
Kazuko Hizukuri, Yasuhiko Fujita, Teruyoshi Amagai
DOI: 10.12659/AJCR.949004
Am J Case Rep 2025; 26:e949004
626 1092 0
04 Dec 2025 : Case report 
A 27-Year-Old Man with Chronic Traumatic Pancreatic Fistula Managed with Percutaneous Microwave Ablation
Raphael AlSarma, Abdel-Rahman Salameh, Talal Sultan M. Althobity, Farooq Bacha, Mohamed Karji Almarzooqi, Iyad Hassan
DOI: 10.12659/AJCR.949541
Am J Case Rep 2025; 26:e949541
710 1,219 0
04 Dec 2025 : Case report
A 27-Year-Old Man with Chronic Traumatic Pancreatic Fistula Managed with Percutaneous Microwave Ablation
Raphael AlSarma, Abdel-Rahman Salameh, Talal Sultan M. Althobity, Farooq Bacha, Mohamed Karji Almarzooqi, Iyad Hassan
DOI: 10.12659/AJCR.949541
Am J Case Rep 2025; 26:e949541
710 1219 0
01 Dec 2025 : Case report
Late-Onset Mesh Infection 10 Years After Right Inguinal Hernia Repair: A Case Report
Ryoichi Shimizu , Masahito Uji, Hideo Matsubara, Yasutomo Miura, Yudai Aoki, Takahiro Maehata, Kazumasa Matsuoka, Yasuji Mokuno
DOI: 10.12659/AJCR.949941
Am J Case Rep 2025; 26:e949941
870 3,610 0
01 Dec 2025 : Case report
Late-Onset Mesh Infection 10 Years After Right Inguinal Hernia Repair: A Case Report
Ryoichi Shimizu , Masahito Uji, Hideo Matsubara, Yasutomo Miura, Yudai Aoki, Takahiro Maehata, Kazumasa Matsuoka, Yasuji Mokuno
DOI: 10.12659/AJCR.949941
Am J Case Rep 2025; 26:e949941
870 3610 0
09 Dec 2025 : Case report
A Rare Case of Emphysematous Pyelonephritis Following Retrograde Intrarenal Surgery in an Elderly Man
Weiyong Zhong , Feihong Xu , Shujiang Ye, Yu Liu, Wei Zhao, Zhenquan Lu, Lin Xiong, Xiang Xu
DOI: 10.12659/AJCR.949018
Am J Case Rep 2025; 26:e949018
753 1,277 0
09 Dec 2025 : Case report
A Rare Case of Emphysematous Pyelonephritis Following Retrograde Intrarenal Surgery in an Elderly Man
Weiyong Zhong , Feihong Xu , Shujiang Ye, Yu Liu, Wei Zhao, Zhenquan Lu, Lin Xiong, Xiang Xu
DOI: 10.12659/AJCR.949018
Am J Case Rep 2025; 26:e949018
753 1277 0
29 Nov 2025 : Case report 
Mixed Cryoglobulinemia in the Setting of Monoclonal B-Cell Lymphocytosis and Monoclonal Gammopathy of Unknown Significance: A Case Report
Eleni Bouziani , Luisa Ladel, Aaron James Stonestrom
DOI: 10.12659/AJCR.949597
Am J Case Rep 2025; 26:e949597
840 1,988 0
29 Nov 2025 : Case report
Mixed Cryoglobulinemia in the Setting of Monoclonal B-Cell Lymphocytosis and Monoclonal Gammopathy of Unknown Significance: A Case Report
Eleni Bouziani , Luisa Ladel, Aaron James Stonestrom
DOI: 10.12659/AJCR.949597
Am J Case Rep 2025; 26:e949597
840 1988 0
07 Dec 2025 : Case report 
Acute Kidney Injury from Mononuclear Cell-Predominated Interstitial Nephritis After Introduction of a Glucagon-Like Peptide-1 Receptor Agonist: A Case Report
Raweekarn Itsathitpaisarn, Nattavong Suksawad, Watsapol Wongwikrom, Jerasit Surintrspanont , Thana Thongsricome
DOI: 10.12659/AJCR.949913
Am J Case Rep 2025; 26:e949913
1,063 2,346 0
07 Dec 2025 : Case report
Acute Kidney Injury from Mononuclear Cell-Predominated Interstitial Nephritis After Introduction of a Glucagon-Like Peptide-1 Receptor Agonist: A Case Report
Raweekarn Itsathitpaisarn, Nattavong Suksawad, Watsapol Wongwikrom, Jerasit Surintrspanont , Thana Thongsricome
DOI: 10.12659/AJCR.949913
Am J Case Rep 2025; 26:e949913
1063 2346 0
09 Dec 2025 : Case report 
Behçet Disease and Cognitive Impairment: A Case Study of an Overlooked Symptom
Caroline Evanthe Nathania , Astuti Prodjohardjono , Noor Alia Susianti , Abdul Gofir , Cempaka Thursina Srie Setyaningrum , Kamala Kan Nur Azza , Ahmad Asmedi , Sri Sutarni
DOI: 10.12659/AJCR.949699
Am J Case Rep 2025; 26:e949699
1,016 2,425 0
09 Dec 2025 : Case report
Behçet Disease and Cognitive Impairment: A Case Study of an Overlooked Symptom
Caroline Evanthe Nathania , Astuti Prodjohardjono , Noor Alia Susianti , Abdul Gofir , Cempaka Thursina Srie Setyaningrum , Kamala Kan Nur Azza , Ahmad Asmedi , Sri Sutarni
DOI: 10.12659/AJCR.949699
Am J Case Rep 2025; 26:e949699
1016 2425 0
30 Nov 2025 : Case report
Improvement of Renal Function in Atrial Fibrillation Patients via Catheter Ablation and Left Atrial Appendage Closure: A Case Report
Jiaying Chen, Caiyun Li, Yuegang Wang, Hongzeng Xu
DOI: 10.12659/AJCR.949421
Am J Case Rep 2025; 26:e949421
977 2,138 0
30 Nov 2025 : Case report
Improvement of Renal Function in Atrial Fibrillation Patients via Catheter Ablation and Left Atrial Appendage Closure: A Case Report
Jiaying Chen, Caiyun Li, Yuegang Wang, Hongzeng Xu
DOI: 10.12659/AJCR.949421
Am J Case Rep 2025; 26:e949421
977 2138 0
06 Dec 2025 : Case report 
Severe Hemoperitoneum From a Ruptured Ovarian Cyst in a Patient with Antiphospholipid Syndrome and Antithrombin III Deficiency: A Case Report
Adrian A. Naoun , Max Ramírez Vázquez, Yandy García Martin, Raysa D. López Torres, Ernesto Garcia Santiago
DOI: 10.12659/AJCR.949379
Am J Case Rep 2025; 26:e949379
1,304 3,772 0
06 Dec 2025 : Case report
Severe Hemoperitoneum From a Ruptured Ovarian Cyst in a Patient with Antiphospholipid Syndrome and Antithrombin III Deficiency: A Case Report
Adrian A. Naoun , Max Ramírez Vázquez, Yandy García Martin, Raysa D. López Torres, Ernesto Garcia Santiago
DOI: 10.12659/AJCR.949379
Am J Case Rep 2025; 26:e949379
1304 3772 0
03 Nov 2025 : Case report
Novel PGM1 Mutation in Congenital Disorder of Glycosylation Type 1T: A Case Report of Liver Failure and Myopathy
Abdulaziz A. Al-Ahmari
DOI: 10.12659/AJCR.948797
Am J Case Rep 2025; 26:e948797
764 1,784 0
03 Nov 2025 : Case report
Novel PGM1 Mutation in Congenital Disorder of Glycosylation Type 1T: A Case Report of Liver Failure and Myopathy
Abdulaziz A. Al-Ahmari
DOI: 10.12659/AJCR.948797
Am J Case Rep 2025; 26:e948797
764 1784 0
28 Nov 2025 : Case report 
Unexpected Schistosomiasis Diagnosed After Appendectomy in a Migrant Child
Isshak Mrabet-Deraoui , Lorenzo Monforte , Slobodan Prica , Yvonne Schmiedel
DOI: 10.12659/AJCR.950906
Am J Case Rep 2025; 26:e950906
774 1,400 0
28 Nov 2025 : Case report
Unexpected Schistosomiasis Diagnosed After Appendectomy in a Migrant Child
Isshak Mrabet-Deraoui , Lorenzo Monforte , Slobodan Prica , Yvonne Schmiedel
DOI: 10.12659/AJCR.950906
Am J Case Rep 2025; 26:e950906
774 1400 0
31 Oct 2025 : Case report
Apical Hypertrophic Cardiomyopathy: Diagnostic Challenges in a Patient with Hypertension and Obstructive Sleep Apnea
Jordan Llerena-Velastegui , Daniela Benitez-Gutierrez, Diego Benitez-Zapata, Camila Escobar-Andrade, Daniela Corral-Hidalgo
DOI: 10.12659/AJCR.950268
Am J Case Rep 2025; 26:e950268
830 2,540 0
31 Oct 2025 : Case report
Apical Hypertrophic Cardiomyopathy: Diagnostic Challenges in a Patient with Hypertension and Obstructive Sleep Apnea
Jordan Llerena-Velastegui , Daniela Benitez-Gutierrez, Diego Benitez-Zapata, Camila Escobar-Andrade, Daniela Corral-Hidalgo
DOI: 10.12659/AJCR.950268
Am J Case Rep 2025; 26:e950268
830 2540 0
In Press
Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.952909
Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.950868
Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.952931
Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.952577
Most Viewed Current Articles
07 Dec 2021 : Case report
22,759,844
DOI :10.12659/AJCR.934347
Am J Case Rep 2021; 22:e934347
06 Dec 2021 : Case report 
176,022
DOI :10.12659/AJCR.934406
Am J Case Rep 2021; 22:e934406
21 Jun 2024 : Case report
120,540
DOI :10.12659/AJCR.944371
Am J Case Rep 2024; 25:e944371
07 Mar 2024 : Case report
65,552
DOI :10.12659/AJCR.943133
Am J Case Rep 2024; 25:e943133